Magnetic Resonance Spectroscopy in Schizophrenia: Evidence for Glutamatergic Dysfunction and Impaired Energy Metabolism.

Magnetic Resonance Spectroscopy in Schizophrenia: Evidence for Glutamatergic Dysfunction and Impaired Energy Metabolism. Neurochem Res. 2018 Apr 03;: Authors: Duarte JMN, Xin L Abstract In the past couple of decades, major efforts were made to increase reliability of metabolic assessments by magnetic resonance methods. Magnetic resonance spectroscopy (MRS) has been valuable for providing in vivo evidence and investigating biomarkers in neuropsychiatric disorders, namely schizophrenia. Alterations of glutamate and glutamine levels in brains of schizophrenia patients relative to healthy subjects are generally interpreted as markers of glutamatergic dysfunction. However, only a small fraction of MRS-detectable glutamate is involved in neurotransmission. Here we review and discuss brain metabolic processes that involve glutamate and that are likely to be implicated in neuropsychiatric disorders. PMID: 29616444 [PubMed - as supplied by publisher]
Source: Neurochemical Research - Category: Neuroscience Authors: Tags: Neurochem Res Source Type: research

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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General LifeHelper Mental Health and Wellness Money and Financial Not Crazy Podcast Stress Source Type: blogs
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Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
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Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
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Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Category: Lipidology Source Type: research
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Source: Journal of Immigrant and Minority Health - Category: International Medicine & Public Health Source Type: research
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Source: New Ideas in Psychology - Category: Psychiatry & Psychology Source Type: research
Conditions:   Quality of Life;   Well-Being;   Compliance, Treatment Intervention:   Behavioral: Group Psychoeducation that Focused on Social Skill Development Sponsor:   Gazi University Completed
Source: - Category: Research Source Type: clinical trials
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