The Combination of Daptomycin plus Fosfomycin has Synergistic, Potent and Rapid Bactericidal Activity against Methicillin-Resistant Staphylococcus aureus (MRSA) in a Rabbit Model of Experimental Endocarditis (EE).

In conclusion, for the treatment of MRSA experimental endocarditis, the combination of daptomycin plus fosfomycin showed synergistic and bactericidal activity.
PMID: 29610194 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - April 2, 2018 Category: Microbiology Authors: García-de-la-Mària C, Gasch O, García-Gonzalez J, Soy D, Shaw E, Ambrosioni J, Almela M, Pericàs JM, Tellez A, Falces C, Hernandez-Meneses M, Sandoval E, Quintana E, Vidal B, Tolosana JM, Fuster D, Llopis J, Pujol M, Moreno A, Marco F, Miró JM, Hospi Tags: Antimicrob Agents Chemother Source Type: research