Infectious Myelopathies

This article reviews bacterial, viral, fungal, and parasitic pathogens associated with myelopathy. Infectious myelopathies may be due to direct infection or parainfectious autoimmune-mediated mechanisms; this article focuses primarily on the former. RECENT FINDINGS Some microorganisms exhibit neurotropism for the spinal cord (eg, enteroviruses such as poliovirus and flaviviruses such as West Nile virus), while others are more protean in neurologic manifestations (eg, herpesviruses such as varicella-zoster virus), and others are only rarely reported to cause myelopathy (eg, certain fungal and parasitic infections). Individuals who are immunocompromised are at increased risk of disseminated infection to the central nervous system. Within the last few years, an enterovirus D68 outbreak has been associated with cases of acute flaccid paralysis in children, and emerging Zika virus infection has been concurrent with cases of acute flaccid paralysis due to Guillain-Barré syndrome, although cases of myelitis have also been reported. Associated pathogens differ by geographic distribution, with myelopathies related to Borrelia burgdorferi (Lyme disease) and West Nile virus more commonly seen in the United States and parasitic infections encountered more often in Latin America, Southeast Asia, and Africa. Characteristic CSF and MRI patterns have been identified with many of these infections. SUMMARY A myriad of pathogens are associated with infectious myelopathies. Host fac...
Source: CONTINUUM: Lifelong Learning in Neurology - Category: Neurology Tags: Review Articles Source Type: research

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ConclusionsMalaria and LF transmission appear absent or extremely low in Dominicanbateyes, which are a mixture of Haitian and Dominican residents. Travel to Haiti is rare, meaning risk of malaria and LF importation is low. Addressing identified gaps in intervention coverage, malaria knowledge, treatment seeking and service delivery will improve the quality of surveillance for these diseases, particularly among marginalized populations and promote island-wide elimination.
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
This study constituted the second phase of a World Anti-Doping Agency (WADA) supported Social Science initiative.
Source: Performance Enhancement and Health - Category: Sports Medicine Source Type: research
Publication date: Available online 25 May 2019Source: American Heart JournalAuthor(s): Alexander C. Fanaroff, Amit N. Vora, Anita Y. Chen, Robin Mathews, Jacob A. Udell, Matthew T. Roe, Laine Thomas, Tracy Y. WangAbstractBackgroundLittle is known about the proportion of hospitals in the United States that offer clinical trial enrollment opportunities and how patient outcomes differ between hospitals that do and do not participate in clinical trials.MethodsIn the nationwide Chest Pain - MI registry, we described the proportion of hospitals that enrolled patients with acute myocardial infarction (MI) in clinical trials from ...
Source: American Heart Journal - Category: Cardiology Source Type: research
In this study, we found that cofilin competes with tau for direct microtubule binding in vitro, in cells, and in vivo, which inhibits tau-induced microtubule assembly. Genetic reduction of cofilin mitigates tauopathy and synaptic defects in Tau-P301S mice and movement deficits in tau transgenic C. elegans. The pathogenic effects of cofilin are selectively mediated by activated cofilin, as active but not inactive cofilin selectively interacts with tubulin, destabilizes microtubules, and promotes tauopathy. These results therefore indicate that activated cofilin plays an essential intermediary role in neurotoxic signaling th...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
(Natural News) Just four days ago, President Trump ordered the declassification of “bucket five” documents which will show how Obama’s FBI and DOJ actively conspired to commit treason against the Trump administration through illegal spying, FISA court fraud, planting spies and more. This is the beginning of the end for the treasonous, criminal deep state...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
(Natural News) Well, it is obvious what the progressive socialist left believes is important. Speaker Nancy Pelosi has clued us in; it is all about President Trump being involved in obstructing justice and being part of a cover-up. As a matter of fact, that has become the new talking point of the left, cover up....
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
(Natural News) Imagine if a Trump-supporting white man stood accused of committing one of the nation’s most prolific and disturbing serial killing sprees against, say, 12 elderly black females. Let’s say authorities claimed this Trump-supporting white man forcibly entered the homes of his victims, one at a time over a period of several years, then...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
In 2015 –2017, the rate of sports, recreation, and leisure injuries among children and adolescents aged 1–17 years was 82.9 per 1,000 population. The rate of sports, recreation, and leisure injuries increased with age from 48.4 for those aged 1–4 y...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
PURPOSE One of the shortcomings of survey trend data on substance use among racial and ethnic groups is not accounting for any criminal history effects. We address this missing piece by examining trends in illicit substance use and binge drinking among th...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
PURPOSE Reciprocal prospective associations between adolescent antisocial behavior and depressive symptoms were examined. Methods Seventh grade students (average age 13  years; N = 2314/2348) were surveyed (T1), and then followed-up 12 (T2) and 24...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
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