Endothelin-1 Decreases Excitability of the Dorsal Root Ganglion Neurons via ET B Receptor

In conclusion, our results demonstrate that ET-1 hyperpolarizes nociceptors by blockingINa and potentiatingIKT through selective activation of ETBR, which may represent one of the underlying mechanisms for reported anti-nociceptive effects of ET-1.

http://link.springer.com/10.1007/s12035-017-0640-1

Source: Molecular Neurobiology - April 4, 2018 Category: Neurology Source Type: research