[Potential Use of Sacran Hydrogels as Wound Dressing Material].

In this study, to develop and characterize sacran hydrogel films (Sac-HGFs) for wound dressing materials, we prepared a physically crosslinked-Sac-HGFs, and evaluated their physicochemical properties, cytotoxicity, skin hydration and wound healing ability. Additionally, we encapsulated curcumin, as a model drug for wound healing, into Sac-HGFs by complexation with 2-hydroxypropyl-γ-cyclodextrin (HP-γ-CyD), and investigated their potential for wound dressing application. Sac-HGF has potentially good properties for wound dressing application, due to not only the moisturizing effect but also the anti-inflammatory effect of sacran. Additionally, Sac-HGF has the potential to deliver water soluble complex of curcumin/HP-γ-CyD at the wound site and thereby promote wound healing. These findings may be useful information for preparation of wound dressing materials using sacran, CyDs and drugs.
PMID: 29607998 [PubMed - in process]

Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 4, 2018 Category: Drugs & Pharmacology Authors: Motoyama K, Higashi T, Okajima MK, Kaneko T, Arima H Tags: Yakugaku Zasshi Source Type: research