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Dysphagia and Oral Morbidities in Chemoradiation-Treated Head and Neck Cancer Patients

This study prospectively evaluated relationships between oral morbidities and swallowing ability in head/neck cancer patients following chemoradiation therapy (CRT) and at 3  months following CRT. Thirty patients with confirmed head/neck cancer undergoing chemoradiation were assessed with a battery of swallowing measures and measures of oral morbidities related to chemoradiation (xerostomia, mucositis, pain, taste/smell, oral moisture). All measures were completed at b aseline (within the first week of CRT), at 6 weeks (end of treatment), and at 3 months following chemoradiation. Descriptive and univariate statistics were used to depict change over time in swallowing and each oral morbidity. Correlation analyses evaluated relationships between swallowing functio n and oral morbidities at each time point. Most measures demonstrated significant negative change at 6 weeks with incomplete recovery at 3 months. At 6 weeks, mucositis ratings, xerostomia, and retronasal smell intensity demonstrated significant inverse relationships with swallowing function. In addition, oral moisture levels demonstrated significant positive relationships with swallowing function. At 3 months, mucositis ratings maintained a significant, inverse relationship with swallow function. Taste and both orthonasal and retronasal smell intensity ratings demonstrated inverse relatio nships with measures of swallow function. Swallow functions and oral morbidities deteriorate si...
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research

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Authors: Jungels C, Martinez Chanza N, Albisinni S, Mercier M, d'Haene N, Rorive S, Roumeguère T Abstract OBJECTIVES: There are only few predictive factors for response of non-musculo-invasive bladder cancer (NMIBC) to Bacillus Calmette-Guérin (BCG) therapy. Our study analyzed the results of the sequencing of new generation (NGS) targeted on 50 genes of oncological interest obtained on bladder resection parts in high-risk NMIBC patients treated with BCG, to describe this population from a molecular point of view and try to correlate these results in patients who present or not recurrence after BCG. ...
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
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Source: Guardian Unlimited Science - Category: Science Authors: Tags: Prostate cancer Health Society UK news Medical research Science Men's health & wellbeing Life and style Source Type: news
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Source: Health News from Medical News Today - Category: Consumer Health News Tags: Women's Health / Gynecology Source Type: news
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Source: Health News from Medical News Today - Category: Consumer Health News Tags: Cancer / Oncology Source Type: news
ConclusionThe presence of oral lesions and the chemotherapeutic regimen were highly associated with nutritional status in older patients with cancer.Clinical relevanceDental professionals should be asked to intervene preventively and per-therapy to optimise oral health status in elderly patients with other cancers than head and neck malignancies.
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research
Conclusions and relevanceNIS negatively influence HNC survivors beyond the acute phase of treatment. These symptoms are associated with decreased nutrition and quality of life. Interventions are necessary to improve survivors ’ eating challenges beyond the completion of treatment. If practitioners do not follow patients long term, patients may suffer consequences of NIS including malnutrition risk, weight loss, and decreased food intake and quality of life. Strategies should be developed to manage NIS and bridge the ga p between short- and long-term health-related outcomes to improve quality of life and survival.
Source: Journal of Cancer Survivorship - Category: Cancer & Oncology Source Type: research
Publication date: Available online 1 February 2018 Source:British Journal of Oral and Maxillofacial Surgery Author(s): H. Boyes, J. Barraclough, R. Ratansi, S.N. Rogers, A. Kanatas The number of clinical trials that relate to patients with cancer of the head and neck is growing. Patient-reported outcomes, which are rarely the primary outcome, are now an important component, and in this structured review to identify and report the characteristics of the questionnaires that have been used in these trials, we summarise the findings reported. We searched several online databases using the key terms: head and neck oncology, he...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
The effectiveness of thyme honey for the management of treatment-induced xerostomia in head and neck cancer patients: A feasibility randomized control trial. Eur J Oncol Nurs. 2017 Apr;27:1-8 Authors: Charalambous A, Lambrinou E, Katodritis N, Vomvas D, Raftopoulos V, Georgiou M, Paikousis L, Charalambous M Abstract PURPOSE: Radiation-induced xerostomia is one of the most common side effects that head and neck cancer patients experience during and after treatment. Despite the various methods for the prevention and treatment of radiation-induced xerostomia, it remains highly prevalent among patien...
Source: European Journal of Oncology Nursing - Category: Nursing Authors: Tags: Eur J Oncol Nurs Source Type: research
The major salivary glands (SG) – parotid (PG), submandibular (SMG), and sublingual – produce up to 90% of all saliva secretion, which is important for the lubrication of the mouth and oropharynx, mastication, teeth remineralization, and microenvironment regulation [1]. Radiation-induced hyposalivation (RIH) and xerostomia (RI X) are the most frequent complications during or after head and neck cancer (HNC) radiotherapy, and they modify salivary flow and composition [2,3]. Both conditions are associated with burning pain; mucosal soreness or ulcerations; impaired taste sensation, chewing, swallowing, wearing den...
Source: Oral Oncology - Category: Cancer & Oncology Authors: Tags: Perspectives Source Type: research
Publication date: Available online 26 February 2016 Source:British Journal of Oral and Maxillofacial Surgery Author(s): S.N. Rogers, N. Heseltine, J. Flexen, H.R. Winstanley, H. Cole-Hawkins, A. Kanatas Health-related quality of life (HRQoL) focuses on 4 core domains: physical and psychological function, social interaction, disease, and treatment-related symptoms, and is a key outcome in patients with cancer of the head and neck. We reviewed papers published between 2006 and 2013 that used validated questionnaires to report functional outcome in this group. A total of 572 papers were identified and 118 of them conc...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
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