Decreased staging of differentiated thyroid cancer in patients with chronic lymphocytic thyroiditis

AbstractPurposeThe biological association between chronic lymphocytic thyroiditis (CLT) and differentiated thyroid cancer (DTC) has not been elucidated yet. The aim of the study was to assess whether the presence of CLT exerts any influence on clinical or histological presentation of DTC.MethodsNine hundred and seven consecutive patients with DTC treated in the years 1998 –2016 were divided into two groups according to the presence or absence of concomitant CLT. The statistical differences were analysed.ResultsOut of 907 patients included in the study, 331 were diagnosed with DTC and CLT (studied group), while 576 patients with DTC but without CLT constituted a control group. The distribution of papillary and follicular thyroid cancer did not differ. In CLT group, the prevalence of pT1 was greater than for pT2 –pT4 DTC (P = 0.0003; OR = 1.69, 95% CI 1.27–2.24) compared to controls (68.3 vs. 56.1%, respectively). The presence of multifocal lesions was similar. The thyroid capsule infiltration without extrathyroidal invasion (P 
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research

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Authors: Krátký J, Ježková J, Kosák M, Vítková H, Bartáková J, Mráz M, Lukáš J, Límanová Z, Jiskra J Abstract The relationship between Hashimoto's thyroiditis (HT) and thyroid cancer (TC) is a controversial topic; it remains unclear if HT acts as a risk factor of TC. The aim of our study was to compare the presence of HT and thyroid function in patients with TC and benign nodules. We analyzed 2571 patients after fine needle aspiration biopsy of thyroid nodule. Totally, 91 patients with primary TC and 182 sex- and age-matched...
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Natascha Roehlen, Claudia Doering, Martin-Leo Hansmann, Frank Gruenwald, Christian Vorlaender, Wolf Otto Bechstein, Katharina Holzer, Klaus Badenhoop, Marissa Penna-Martinez
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Publication date: September 2018Source: Human Pathology: Case Reports, Volume 13Author(s): Mir Wajahat, Tazeen Jeelani, Kanika Gupta, Nusrat BashirAbstractWarthin-like variant is one of the histologic variants of papillary thyroid cancer that has rarely been reported. It is classically seen in females over the age of 50 years. Clinical presentation and prognosis is similar to that of classic papillary thyroid cancer. Its frequent association with Hashimoto's thyroiditis and unique morphological features make it easily recognizable on histologic examination. The cytological diagnosis is difficult due to the overlap of fin...
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research
Conclusion: Even though NF1 patients did not show an increased risk of thyroid incidentaloma on PET/CT compared to previous studies on non-thyroid cancer patients, the incidence shows that awareness of possible thyroid disease is important.Eur Thyroid J
Source: European Thyroid Journal - Category: Endocrinology Source Type: research
In this study, we examined the expression of PD-L1, PD-1, and BRAF V600E in PTC by immunohistochemistry and investigated the clinical significance of expression status. We studied the expression of PD-L1, PD-1, and BRAF V600E by immunohistochemical staining in 110 cases of PTC with a diameter>  1 cm. Cases with a background of chronic lymphocytic thyroiditis (CLT) were excluded, as differentiating lymphocytes in the context of CLT from tumor-infiltrating lymphocytes (TILs) is difficult. We classified PD-L1+/PD-1+ expression as type 1 (41%), PD-L1−/PD-1− as type 2 (17%), PD-L1+/PD-1 − as typ...
Source: Virchows Archiv - Category: Pathology Source Type: research
Publication date: September 2018 Source:Human Pathology: Case Reports, Volume 13 Author(s): Mir Wajahat, Tazeen Jeelani, Kanika Gupta, Nusrat Bashir Warthin-like variant is one of the histologic variants of papillary thyroid cancer that has rarely been reported. It is classically seen in females over the age of 50 years. Clinical presentation and prognosis is similar to that of classic papillary thyroid cancer. Its frequent association with Hashimoto's thyroiditis and unique morphological features make it easily recognizable on histologic examination. The cytological diagnosis is difficult due to the overlap of findings...
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research
CONCLUSIONS: The prevalence of thyroid nodules in children and adolescents with HT was 22.4%. The malignancy rate of children with HT was 7.9%. The malignancy rate among thyroid nodules was 35%, which is higher than the 26% rate generally reported for children with nodules. Therefore, using thyroid US to survey known or suspected thyroid nodules might be helpful in children and adolescents with HT and may provide further useful diagnostic information. Advances in Knowledge: Thyroid US could help to assess HT patients who have known or suspected thyroid nodules. PMID: 29595320 [PubMed - as supplied by publisher]
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
In conclusion, the prescription of supplements with organic forms of Se must be preferred against of supplements with inorganic forms of Se among DTC patients for the protection of their salivary glands from 131I treatment and Brazil nuts could be another choice. PMID: 29550852 [PubMed - as supplied by publisher]
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
CONCLUSION: Incidental PTMC is more often detected in patients that undergo surgery for multinodular goitre and Hashimoto's thyroiditis. Total thyroidectomy constitutes a safe and adequate surgical approach in patients with PTMC. PMID: 29553616 [PubMed]
Source: B-ENT - Category: ENT & OMF Tags: B-ENT Source Type: research
Conclusions: CLT in patients with PTC was associated with lower-stage disease and less disease persistence in patients #x3e;45 years of age. In patients #x3c;45 years, the presence of CLT appeared to be associated with unfavorable pathological features.Eur Thyroid J
Source: European Thyroid Journal - Category: Endocrinology Source Type: research
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