Decreased staging of differentiated thyroid cancer in patients with chronic lymphocytic thyroiditis
AbstractPurposeThe biological association between chronic lymphocytic thyroiditis (CLT) and differentiated thyroid cancer (DTC) has not been elucidated yet. The aim of the study was to assess whether the presence of CLT exerts any influence on clinical or histological presentation of DTC.MethodsNine hundred and seven consecutive patients with DTC treated in the years 1998 –2016 were divided into two groups according to the presence or absence of concomitant CLT. The statistical differences were analysed.ResultsOut of 907 patients included in the study, 331 were diagnosed with DTC and CLT (studied group), while 576 patients with DTC but without CLT constituted a control group. The distribution of papillary and follicular thyroid cancer did not differ. In CLT group, the prevalence of pT1 was greater than for pT2 –pT4 DTC (P = 0.0003; OR = 1.69, 95% CI 1.27–2.24) compared to controls (68.3 vs. 56.1%, respectively). The presence of multifocal lesions was similar. The thyroid capsule infiltration without extrathyroidal invasion (P
Publication date: September 2018Source: Human Pathology: Case Reports, Volume 13Author(s): Mir Wajahat, Tazeen Jeelani, Kanika Gupta, Nusrat BashirAbstractWarthin-like variant is one of the histologic variants of papillary thyroid cancer that has rarely been reported. It is classically seen in females over the age of 50 years. Clinical presentation and prognosis is similar to that of classic papillary thyroid cancer. Its frequent association with Hashimoto's thyroiditis and unique morphological features make it easily recognizable on histologic examination. The cytological diagnosis is difficult due to the overlap of fin...
Conclusion: Even though NF1 patients did not show an increased risk of thyroid incidentaloma on PET/CT compared to previous studies on non-thyroid cancer patients, the incidence shows that awareness of possible thyroid disease is important.Eur Thyroid J
In this study, we examined the expression of PD-L1, PD-1, and BRAF V600E in PTC by immunohistochemistry and investigated the clinical significance of expression status. We studied the expression of PD-L1, PD-1, and BRAF V600E by immunohistochemical staining in 110 cases of PTC with a diameter> 1 cm. Cases with a background of chronic lymphocytic thyroiditis (CLT) were excluded, as differentiating lymphocytes in the context of CLT from tumor-infiltrating lymphocytes (TILs) is difficult. We classified PD-L1+/PD-1+ expression as type 1 (41%), PD-L1−/PD-1− as type 2 (17%), PD-L1+/PD-1 − as typ...
Publication date: September 2018 Source:Human Pathology: Case Reports, Volume 13 Author(s): Mir Wajahat, Tazeen Jeelani, Kanika Gupta, Nusrat Bashir Warthin-like variant is one of the histologic variants of papillary thyroid cancer that has rarely been reported. It is classically seen in females over the age of 50 years. Clinical presentation and prognosis is similar to that of classic papillary thyroid cancer. Its frequent association with Hashimoto's thyroiditis and unique morphological features make it easily recognizable on histologic examination. The cytological diagnosis is difficult due to the overlap of findings...
CONCLUSIONS: The prevalence of thyroid nodules in children and adolescents with HT was 22.4%. The malignancy rate of children with HT was 7.9%. The malignancy rate among thyroid nodules was 35%, which is higher than the 26% rate generally reported for children with nodules. Therefore, using thyroid US to survey known or suspected thyroid nodules might be helpful in children and adolescents with HT and may provide further useful diagnostic information. Advances in Knowledge: Thyroid US could help to assess HT patients who have known or suspected thyroid nodules. PMID: 29595320 [PubMed - as supplied by publisher]
In conclusion, the prescription of supplements with organic forms of Se must be preferred against of supplements with inorganic forms of Se among DTC patients for the protection of their salivary glands from 131I treatment and Brazil nuts could be another choice. PMID: 29550852 [PubMed - as supplied by publisher]
CONCLUSION: Incidental PTMC is more often detected in patients that undergo surgery for multinodular goitre and Hashimoto's thyroiditis. Total thyroidectomy constitutes a safe and adequate surgical approach in patients with PTMC. PMID: 29553616 [PubMed]
Conclusions: CLT in patients with PTC was associated with lower-stage disease and less disease persistence in patients #x3e;45 years of age. In patients #x3c;45 years, the presence of CLT appeared to be associated with unfavorable pathological features.Eur Thyroid J
ConclusionsOur data suggest that concurrent CLT has a protective effect on PTC outcome and that the imbalance between cytotoxic and regulatory T lymphocytes in the peri-tumoral TAL may affect the tumor-specific immune response favoring a more aggressive behavior of cancer.
Antonio Ieni, Roberto Vita, Emilia Magliolo, Mariacarmela Santarpia, Flavia Di Bari, Salvatore Benvenga, Giovanni Tuccari