Median nerve stimulation prevents atrial electrical remodelling and inflammation in a canine model with rapid atrial pacing

ConclusionsThe effects of MNS on atrial electrical remodelling and AF inducibility might be associated with the cholinergic anti-inflammatory pathway.
Source: Europace - Category: Cardiology Source Type: research

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In this study, we briefly explained the molecular genetics of DMD and a historical overview of DMD gene therapy. We in particular focused on CRISPR/Cas9-mediated therapeutic approaches that used to treat DMD.
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
Authors: Wang M, Li J, Zheng Y Abstract Nuclear factor erythroid 2-related factor 2 (Nrf2) acts as a regulator of many biological processes and plays an essential role in preventing oxidation, inflammation, and fibrosis. In the past 20 years, there has been increasing research on the role of Nrf2 and oxidative stress in human glaucoma, including the roles of inflammation, trabecular meshwork cells, retinal ganglion cells, Tenon's capsule, antioxidants, fibrosis, and noncoding RNAs. Studies have shown that the upregulation of Nrf2 can reduce damage from oxidative stress in the trabecular meshwork cells and the retin...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Publication date: Available online 17 January 2020Source: International Journal of Pediatrics and Adolescent MedicineAuthor(s): Haya S. AlFaris, Ghasan Elhissi, Aziza Chedrawi, Mohammad Al-MuhaizeaAbstractRecessive congenital methemoglobinemia (RCM) is a rare neurological disorder caused by a deficiency in NADH-CYB5R. RCM has two main types I&II, with cyanosis being the hallmark feature in both. Type-I is a mild form, with cyanosis being the only feature. While type-II is the severe form with prominent neurological symptoms including, dystonia and spasticity. However, the cyanosis is subtle and difficult to appreciate. The...
Source: International Journal of Pediatrics and Adolescent Medicine - Category: Pediatrics Source Type: research
In this study, we assessed the impact of interacting medication and pharmacogenetic variation to better explain apixaban concentration differences among 358 Caucasian AF patients. Genotyping (ABCG2,ABCB1,CYP3A4*22,CYP3A5*3) was performed by TaqMan assays, and apixaban quantified by mass spectrometry. The typical patient was on average 77.2  years old, 85.5 kg, and had a serum creatinine of 103.1 µmol/L. Concomitant amiodarone, an antiarrhythmic agent and moderate CYP3A/ABCB1 inhibitor, the impaired-function variantABCG2 c.421C  >  A, and sex predicted higher apixaban concentrations whe...
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
In this study the use of ad-hoc designed reagents and catcher molecules was able to accurately identify DOAs activity at ROTEM.
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
Atrial fibrillation can be a presenting sign of primary aldosteronism in patients with hypertension, according to findings from the PAPPHY study.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Cardiology News Source Type: news
ConclusionsThis study demonstrated that renal sympathetic nerve activation induced by 3 hours of P‐RSS facilitated atrial fibrillation inducibility by upregulating cardiac autonomic nervous activity, suggesting a potential autonomic cross talk between kidney and heart.
Source: JAHA:Journal of the American Heart Association - Category: Cardiology Authors: Tags: Atrial Fibrillation, Autonomic Nervous System Original Research Source Type: research
The impact of ablation of ganglionated plexuses (GPs) during ablation of atrial fibrillation (AF) on ventricular myocardial innervation is unknown. Previous animal studies have shown different electrophysiological outcomes of ventricular myocardial denervation after ablation of autonomic ganglia.1,2 A recent animal report demonstrated that the ligament of Marshall could represent a conduit between the left stellate ganglion and the ventricle.2 There have been no reports evaluating detailed GP mapping and ablation in the atria and potential effects on ventricular sympathetic myocardial innervation.
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research
Atrial arrhythmia, which includes atrial fibrillation (AF) and atrial flutter (AFL), is common in patients with pulmonary arterial hypertension (PAH), who often have increased sympathetic nerve activity. Here, we tested the hypothesis that autonomic nerves play important roles in vulnerability to AF/AFL in PAH. The atrial effective refractory period and AF/AFL inducibility at baseline and after anterior right ganglionated plexi ablation were determined during left stellate ganglion stimulation or left renal sympathetic nerve stimulation in beagle dogs with or without PAH. Then, sympathetic nerve, β-adrenergic receptor...
Source: Hypertension - Category: Cardiology Authors: Tags: Atrial Fibrillation, Basic Science Research, Pulmonary Hypertension, Arrythmias-basic studies, Other hypertension Nervous System Source Type: research
The autonomic nervous system plays an important role in the modulation of cardiac arrhythmogenesis, and autonomic nerve activity can act as a direct trigger of arrhythmias. In atrial fibrillation, sympathetic left stellate ganglion (LSG) and atrial gonglionated plexus activations(GP) are the most common trigger [1].
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Letters to the Editor Source Type: research
More News: Atrial Fibrillation | Ganglions | Reflex Sympathetic Dystrophy | Study