Catheter ablation for ventricular tachycardia in patients with cardiac sarcoidosis: a systematic review

AbstractAimsCardiac sarcoidosis (CS) is associated with a poor prognosis. Important features of CS include heart failure, conduction abnormalities, and ventricular arrhythmias. Ventricular tachycardia (VT) is often refractory to antiarrhythmic drugs (AAD) and immunosuppression. Catheter ablation has emerged as a treatment option for recurrent VT. However, data on the efficacy and outcomes of VT ablation in this context are sparse.Methods and resultsA systematic search was performed on PubMed, EMBASE, and Cochrane database (from inception to September 2016) with included studies providing a minimum of information on CS patients undergoing VT ablation: age, gender, VT cycle length, CS diagnosis criteria, and baseline medications. Five studies reporting on 83 patients were identified. The mean age of patients was 50  ± 8 years, 53/30 (males/females) with a maximum of 56 patients receiving immunosuppressive therapy, mean ejection fraction was 39.1 ± 3.1% and 94% had an implantable cardioverter defibrillatorin situ. The median number of VTs was 3 (2.6 –4.9)/patient, mean cycle length of 360 ms (326–400 ms). Hundred percent of VTs received endocardial ablation, and 18% required epicardial ablation. The complication rates were 4.7–6.3%. Relapse occurred in 45 (54.2%) patients with an incidence of relapse 0.33 (95% confidence interval 0.10 8–0.551,P 
Source: Europace - Category: Cardiology Source Type: research

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Publication date: Available online 20 January 2020Source: Artificial Intelligence in MedicineAuthor(s): Oh Shu Lih, V Jahmunah, Tan Ru San, Edward J Ciaccio, Toshitaka Yamakawa, Masayuki Tanabe, Makiko Kobayashi, Oliver Faust, U Rajendra AcharyaAbstractCardiovascular disease (CVD) is the leading cause of death worldwide, and coronary artery disease (CAD) is a major contributor. Early-stage CAD can progress if undiagnosed and left untreated, leading to myocardial infarction (MI) that may induce irreversible heart muscle damage, resulting in heart chamber remodeling and eventual congestive heart failure (CHF). Electrocardiog...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
CONCLUSIONS: According to the above results, our study revealed that LUCAT1 was decreased in CHF patients, which was correlated with poor prognosis of CHF patients. Furthermore, the downregulation of LUCAT1 inhibited cell proliferation and promoted cell apoptosis via targeting miR-612/HOXA13 axis. Our results elucidated a potential mechanism underlying cardiomyocyte apoptosis, which might be used as a promising prognostic marker and a potential target for CHF patients. PMID: 31957853 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: Multi-hormonal deficiencies are associated with right ventricular dysfunction and diastolic dysfunction in patients with HFpEF. PMID: 31957849 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Jr-Wei Chen, Yi-Ling Lin, Chung-Hsi Chou, Yi-Hsieng Samuel Wu, Sheng-Yao Wang, Yi-Chen ChenAbstractA high-fat diet is a major risk factor for obesity and heart failure. Our previous study has demonstrated that protease A-digested crude-chalaza hydrolysates (CCH-As) with a specific free amino-acid and carnosine/anserine profile show lipid-lowering and antioxidant activities against chronic alcohol consumption. The antiobesity and hypolipidemic effects of our CCH-As against a high-fat diet was to investigated in this study. In high-fat-diet ...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
A 78-year-old woman was admitted because of heart failure. She was known to have nonischemic dilated cardiomyopathy. During the past 2 weeks, she developed severe shortness of breath. The people around her also noticed memory loss and confusion in time and place, suggesting that she was becoming demented. On admission, her daily medication consisted of a β-blocking agent, an angiotensin-converting enzyme inhibitor, a diuretic, and 1/8 mg of digoxin.
Source: Heart Rhythm - Category: Cardiology Authors: Tags: Josephson and Wellens ECG Lessons: A Monthly Visit to the 12 Lead ECG Source Type: research
Conclusion: Regional electrophysiology and paths in the model match human action potentials, dynamic behavior, and cardiac activation sequences. Connected in closed loop with a pacing device in DDD mode, the model generates complex arrhythmia such as atrioventricular nodal reentry tachycardia. Such device-induced outcomes have been observed clinically and we can establish the key physiological features of the heart model that influence the device operation. Significance: These findings demonstrate how an abstract heart model can be used for device validation and to design personalized treatment.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
The field of medical AI is buzzing. More and more companies set the purpose to disrupt healthcare with the help of artificial intelligence. Given how fast these companies come and go, it can prove to be hard to stay up-to-date with the most promising ones. Here, I collected the biggest names currently on the market ranging from start-ups to tech giants to keep an eye on in the future. To further help you keep up with what A.I. brings to medicine, The Medical Futurist team made an easy-to-digest e-book about just that. I highly encourage you to read it and would love to hear about your thoughts! Artificial Intelligence has ...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Artificial Intelligence Healthcare Design AI digital health genetics Innovation Personalized medicine pharma GC1 big data drug development healthcare companies medical imaging Source Type: blogs
This article reviews the current drug therapies and their use in the management of PAH in children.
Source: Pediatric Drugs - Category: Pediatrics Source Type: research
AbstractThe2015 HRS/EHRA/APHRS/SOLAECE Expert Consensus Statement on Optimal Implantable Cardioverter-Defibrillator Programming and Testing provided guidance on bradycardia programming, tachycardia detection, tachycardia therapy, and defibrillation testing for implantable cardioverter-defibrillator (ICD) patient treatment. The 32 recommendations represented the consensus opinion of the writing group, graded by Class of Recommendation and Level of Evidence. In addition, Appendix B provided manufacturer-specific translations of these recommendations into clinical practice consistent with the recommendations within the parent...
Source: Journal of Interventional Cardiac Electrophysiology - Category: Cardiology Source Type: research
AimGuanidinoacetate N-methyltransferase (GAMT) is the second essential enzyme in creatine (Cr) biosynthesis. Short-term Cr deficiency is metabolically well tolerated as GAMT–/– mice exhibit normal exercise capacity and response to ischemic heart failure. However, we hypothesized long-term consequences of Cr deficiency and/or accumulation of the Cr precursor guanidinoacetate (GA).MethodsCardiac function and metabolic profile were studied in GAMT–/– mice>1 year.ResultsIn vivo LV catheterization revealed lower heart rate and developed pressure in aging GAMT–/– but normal lung weight and ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
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