Paligenosis: prepare to regenerate!

Tissue injury can stimulate quiescent cells to proliferate, resulting in metaplasia, to rapidly replace damaged cells and enable regeneration. A new study describes how fully differentiated cells return to proliferation in an autophagy- and mTORC1-dependent manner. Given the striking parallels between this process in mammalian stomach and pancreas, a new term, paligenosis, is proposed for this conserved program.

Source: EMBO Journal - April 3, 2018 Category: Molecular Biology Authors: Messal, H. A., Cremona, C. A., Lan, L., Behrens, A. Tags: Cell Cycle, Autophagy & Cell Death, Development & Differentiation News [amp ] Views Source Type: research