Mp19-06 novel measures of sperm dna damage increase its usefulness to diagnose male infertility and predict live births following both ivf and icsi

Sperm DNA fragmentation is a biomarker of male infertility and results in poorer IVF outcomes. The Comet assay measures the DNA damage in individual sperm enabling the degree of heterogeneity of the whole sperm population to be assessed. The aim of this study was to explore the impact of this heterogeneity, assess the diagnostic and predictive power of novel Comet parameters that quantify different damage levels in the semen sample. We also determined if quantifying the proportion of sperm with low or high DNA damage increases the predictive value of Comet test for the diagnosis of male infertility and prediction of ART live birth rates.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Infertility: Epidemiology & Evaluation II Source Type: research