Pd14-12 secondary outcomes of a prospective randomized trial of dietary carbohydrate restriction for men initiating androgen deprivation therapy: carbohydrate and prostate study i (caps1)

Metabolic side effects of androgen deprivation therapy (ADT) include diabetes, weight gain, increased fat mass, and osteoporosis. We previously showed in the CAPS1 trial that restricting carb intake in overweight men starting ADT led to weight and fat mass loss, suggestively improved insulin sensitivity, and reduced bone mass loss, thus reducing the risk of ADT-associated side effects vs. a control arm (no lifestyle changes). Here, we present secondary outcomes. We hypothesized a low-carb diet would favorably impact cholesterol, HbA1c, and HsCRP levels (a measure of systemic inflammation) without increasing adverse events (AEs).

Source: The Journal of Urology - April 1, 2018 Category: Urology & Nephrology Authors: Stephen Freedland, William Aronson, Lauren Howard, Jordan Smith, Matthew Smith, Jennifer Stout, Jenifer Allen, Daniel George, Andrew Armstrong, Brant Inman, Pao-Hwa Lin Tags: Prostate Cancer: Advanced (including Drug Therapy) II Source Type: research