Mp28-08 clinicopathologic and genomic evaluation of translocation renal cell carcinoma

Translocation renal cell carcinomas (tRCC) represent 1-5% of all RCCs and are associated with aggressive disease and poor outcomes. tRCCs uniformly contain gene fusions of either transcription factor E3 (TFE3) or transcription factor EB (TFEB) with various partners, or rarely, TFEB amplification. However, given the rarity of these tumors, much remains unknown about other important genomic drivers of this disease.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Kidney Cancer: Epidemiology & Evaluation/Staging I Source Type: research