V04-08 segmental ureterectomy with buccal mucosa graft reconstruction in a patient with lynch syndrome and upper tract urothelial carcinoma

We present a 59 year-old female with Lynch Syndrome and a 3 cm low-grade UTUC in the right mid ureter on a CT scan for abdominal pain. Patient elected for segmental ureterectomy with a buccal mucosa graft reconstruction due to location of the tumor and risk of bilateral disease.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Reconstruction - Upper Urinary Tract Source Type: research

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In this study, we performed immunohistochemistry (IHC) assay. The results show that RASSF6 is upregulated in ESCC and that the elevated expression level of RASSF6 is associated with lymph node metastasis and poor survival of ESCC patients. Consistent with the clinical observations, the upregulation of RASSF6 greatly promotes ESCC cell proliferation, migration and invasion as well as the cell cycle transition to G1/S phase in vitro. According to models in vivo, the downregulation of RASSF6 considerably inhibits ESCC tumor growth and lung metastasis. Mechanistically, RASSF6 negatively regulates the tumor suppressor tripartit...
Source: Journal of Genetics and Genomics - Category: Genetics & Stem Cells Source Type: research
Abstract Polymorphisms in the LPA gene have been associated with aortic valve calcification (AVC). There are wide differences in the allelic frequencies, Lp(a) levels, and the association with AVC among ethnic groups. The aim of this study was to determine the association of the LPA gene polymorphisms with Lp(a) levels and risk of developing AVC, in Mexican-Mestizos population. Six LPA polymorphisms (rs10455872, rs7765803, rs6907156, rs1321195, rs12212807 and rs6919346) were genotyped by TaqMan assays in 1,265 individuals without premature coronary artery disease. The presence of AVC was determined by computed tomography. ...
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research
Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type globally and contributes significantly to burden of disease in South Asia. In Pakistan, HNSCC is among the most commonly diagnosed cancer in males and females. The increasing regional burden of HNSCC along with a unique set of risk factors merited a deeper investigation of the disease at the genomic level. Whole exome sequencing of HNSCC samples and matched normal genomic DNA analysis (n=7) was performed. Significant somatic single nucleotide variants (SNVs) were identified and pathway analysis performed to determine frequently affe...
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research
Publication date: November 2019Source: International Journal of Industrial Ergonomics, Volume 74Author(s): Trond Kongsvik, Øyvind Dahl, Ingunn Marie Holmen, Trine ThorvaldsenAbstractFew studies have explored the potential connection between safety climate and health issues. However, some recent research findings indicate that a poor safety climate can be considered a stressor that may be associated with physical symptoms and musculoskeletal complaints. This link is further explored in the present study on the basis of a questionnaire study of 446 sharp-end workers in the Norwegian aquaculture industry. The analysis ...
Source: International Journal of Industrial Ergonomics - Category: Occupational Health Source Type: research
Publication date: January 2020Source: Urology Case Reports, Volume 28Author(s): C. Darr, U. Krafft, A. Panic, S. Tschirdewahn, B.A. Hadaschik, C. RehmeAbstractMeyer-Weigert-Rule predicts the draining pattern of duplex ureters in bipolar renal duplications. The upper pole is normally seen as ectopic and therefore dysplastic due to obstruction, whereas the lower pole is related to vesicoureteral reflux. In our case, this rule is violated with uncrossed ureter duplex and a dysplastic lower pole in connection with obstruction.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
ConclusionsA policy of selective histopathology after cholecystectomy is oncologically safe and reduces costs.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Conclusions Surgical repair with muscle flap coverage, with or without ligation of profunda femoris artery, does not affect prognosis. An alternative method for identifying healthy segments of femoral artery may be frozen section and examination of the artery to decrease the risk of recurrence at the site of anastomosis.RESUMO Contexto A doen ça de Behçet (DB) é uma enfermidade autoimune que envolve múltiplos sistemas. A manifestação arterial mais comum em pacientes com DB é o pseudoaneurisma, que tem uma frequência mais alta do que a formação de aneurism...
Source: Jornal Vascular Brasileiro - Category: Surgery Source Type: research
Resumo A s índrome da congestão pélvica (SCP) é definida como dor pélvica crônica há mais de 6 meses associada a varizes perineais ou vulvares, resultantes do refluxo ou obstrução das veias gonadais, glúteas ou periuterinas. A SCP é responsável por 16-31% dos casos de dor pélvica crônica, sendo d iagnosticada sobretudo na terceira e quarta décadas de vida. Nos últimos anos, houve um interesse maior nessa patologia por parte dos cirurgiões vasculares devido à sua associação com insufici&e...
Source: Jornal Vascular Brasileiro - Category: Surgery Source Type: research
Authors: Yu L, Yang Y, Wang C Abstract This chapter intends to review the progress in obtaining site-specific structural information for peptide assemblies using scanning tunneling microscopy. The effects on assembly propensity due to mutations and modifications in peptide sequences, small organic molecules and conformational transitions of peptides are identified. The obtained structural insights into the sequence-dependent assembly propensity could inspire rational design of peptide architectures at the molecular level. PMID: 31713196 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Introduction Exercise therapy (ET) is advocated as a treatment for chronic nonspecific low back pain (CNSLBP). However, therapy effect sizes remain low. In other chronic disorders, training at higher intensity has resulted in greater improvements on both general health related and disease specific outcomes compared to lower-intensity ET. Possibly, high-intensity training also improves effect sizes in CNSLBP. Objective To compare the effects of a high-intensity ET program with a similar moderate-intensity ET program on disability, pain, function, exercise capacity, and abdominal/back muscle strength in persons with CNS...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research
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