Pd33-09 mir-135a is associated with cryptorchidism infertility through suppression of foxo1 in spermatogonial stem cells

Spermatogonial stem cells (SSCs) function as a life-long spermatogenesis reserve. Self-renewal and stem maintenance are foundational characteristics of SSCs. To maintain these cellular characteristics, the regulation of genome transcription is mandatory, although the basis of this mechanism remains unknown. Recently, small mRNA, called microRNA (miRNA), consisting of 18 –25 nucleotide bases have been recognized as key transcription regulators. The effect involves more than one-third of all transcription regulation.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Stem Cell Research: Stem Cell Research I Source Type: research