Mp60-01 hedgehog signalling enhances subcutaneous leydig stem cell autograft survival and testosterone production

Exogenous testosterone supplementation can be used to treat low testosterone; however, it has several adverse effects including infertility due to negative feedback on the hypothalamic-pituitary-gonadal (HPG) axis. We evaluated the feasibility of subcutaneously autografting Leydig stem cells (LSC) in combination with Sertoli and myoid cells to increase testosterone. Furthermore, we evaluated the mechanism essential for survival of LSC in extra-testicular milieu.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Infertility: Basic Research & Pathophysiology Source Type: research