Mp88-13 tumor suppressor tsc1 is a new hsp90 cochaperone that facilitates folding of kinase and non-kinase clients

Mutation of either TSC1 or TSC2 causes tuberous sclerosis, a multisystem genetic syndrome that can lead to formation of benign tumors in the kidneys, lungs, and other organs and has also been linked to epilepsy and autism. The tumor suppressors Tsc1 and Tsc2 form the tuberous sclerosis complex (TSC), a regulator of mTOR activity. Tsc1 stabilizes Tsc2; however the precise mechanism remains elusive. Molecular chaperones such as heat shock protein-90 (Hsp90) are essential for the stability and activation of numerous signaling proteins, including tumor suppressors.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Kidney Cancer: Basic Research & Pathophysiology III Source Type: research