EPHX1 rs1051740 T > C (Tyr113His) is strongly associated with acute myeloid leukemia and KMT2A rearrangements in early age.
In conclusion, EPHX1 rs1051740 plays an important role in i-AML's genetic susceptibility by modulating the carcinogenic effects of epoxide exposures in the bone marrow.
PMID: 29605894 [PubMed - as supplied by publisher]
Source: Archives of Toxicology - Category: Toxicology Authors: Brisson GD, de Almeida Lopes B, Andrade FG, Dos Santos Bueno FV, Sardou-Cezar I, de Aguiar Gonçalves BA, Terra-Granado E, ParaguassĂș-Braga FH, S Pombo-de-Oliveira M Tags: Arch Toxicol Source Type: research
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