Kidney age, not kidney disease

There should be a rethink in how doctors talk to some patients with reduced kidney health, replacing the term ‘ chronic kidney disease ’ (CKD) with different bands of kidney age, according to a group of experts including University of Bristol researchers, writing in the Canadian Medical Association Journal.
Source: University of Bristol news - Category: Universities & Medical Training Tags: Health, Research; Faculty of Health Sciences, Faculty of Health Sciences, Bristol Medical School; Press Release Source Type: news

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ConclusionsOur results provide evidence that PROMIS-57 and PROMIS-29 are highly reliable and valid instruments among kidney transplant recipients. We propose it as a valuable tool to assess important domains of the illness experience.
Source: Quality of Life Research - Category: Health Management Source Type: research
Conclusions: Our data indicate that higher TSH concentrations are positively correlated with CKD prevalence and that  a high TSH concentration is a risk factor for CKD development.Nephron
Source: Nephron - Category: Urology & Nephrology Source Type: research
Publication date: Available online 21 February 2019Source: American Journal of Kidney DiseasesAuthor(s): Vimal K. Derebail, Emily J. Ciccone, Qingning Zhou, R. Rosina Kilgore, Jianwen Cai, Kenneth I. AtagaRationale &ObjectiveProgression of chronic kidney disease (CKD) in sickle cell disease (SCD) and its risk factors remain poorly defined. We identified characteristics associated with CKD as well as decline in estimated glomerular filtration rate (eGFR) and presence of proteinuria over time in adults with SCD.Study DesignRetrospective observational study.Setting &ParticipantsPatients with SCD 18 years or older in a...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
ConclusionsCKD stage 3 was not associated with an increase in fracture status. QUS parameters were similarly associated with fracture status in patients with and without CKD.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
DISCUSSION: Physical activity, diet, body mass index, the presence of diabetes, and the presence of chronic kidney disease were strong risk factors for hypertension. Many of these risk factors are modifiable and highlight targets for future prevention strategies. PMID: 30785634 [PubMed - in process]
Source: Health Reports - Category: International Medicine & Public Health Tags: Health Rep Source Type: research
Circulating C3 has been associated with diabetes and hypertension, which are the leading causes of chronic kidney disease (CKD). C3 activation is considered to contribute to several renal diseases. Here we exa...
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Research article Source Type: research
Publication date: Available online 19 February 2019Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Laura Ferreras, Anna Moles, Gerhard R. Situmorang, Rana el Masri, Imogen L. Wilson, Katie Cooke, Emily Thompson, Marion Kusche-Gullberg, Romain R. Vivès, Neil S. Sheerin, Simi AliAbstractOne of the main feature of chronic kidney disease is the development of renal fibrosis. Heparan Sulfate (HS) is involved in disease development by modifying the function of growth factors and cytokines and creating chemokine gradients. In this context, we aimed to understand the function of HS sulfation in rena...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research
Condition:   Chronic Kidney Diseases Interventions:   Behavioral: PRO-based follow-up;   Behavioral: PRO-based telephone consultation Sponsors:   University of Aarhus;   Regional Hospital West Jutland;   Aarhus University Hospital;   TrygFonden, Denmark;   Karen Elise Jensen Foundation;   Sygekassernes Helsefond Active, not recruiting
Source: - Category: Research Source Type: clinical trials
Nephrons scar and involute during aging, increasing the risk of chronic kidney disease. Little is known, however, about genetic mechanisms of kidney aging. We sought to define the signatures of age on the renal transcriptome using 563 human kidneys. The initial discovery analysis of 260 kidney transcriptomes from the TRANScriptome of renaL humAn TissuE Study (TRANSLATE) and the Cancer Genome Atlas identified 37 age-associated genes. For 19 of those genes, the association with age was replicated in 303 kidney transcriptomes from the Nephroseq resource.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Clinical Investigation Source Type: research
Tubulointerstitial fibrosis is considered a hallmark of maladaptive repair processes after tubular injury leading to chronic kidney disease. Nakamura and colleagues show that, upon injury, myofibroblasts promote epithelial repair by producing retinoic acid in place of injured tubular cells. These results suggest that resident fibroblasts turning into myofibroblasts maintain a cross-talk that protects tubular epithelial cells from injury and can restore tissue integrity and functionality, challenging the concept that fibrosis is only detrimental in nature.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
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