Influence of Prednisolone on Parameters of De Novo Lipogenesis and Indices for Stearoyl-CoA- and Δ6- desaturase Activity in Healthy Males: A Post-hoc analysis of a Randomized, Placebo-Controlled, Double-Blind Trial

Glucocorticoids (such as prednisolone) are anti-inflammatory drugs commonly used to treat both acute and chronic inflammatory diseases, including gout, pulmonary infection, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and psoriasis [1,2]. Intake of glucocorticoids is high, especially in the US, where the prevalence of oral glucocorticoids in the general population is around 1.2% [3]. Glucocorticoid treatment is associated with multiple adverse effects, including systemic hypertension, impaired glucose metabolism and overt diabetes, dyslipidemia, osteoporosis, muscle and skin atrophy and increased susceptibility to infections [4 –9].

Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - April 2, 2018 Category: Biomedical Science Authors: I.G. Pranger, D.H. van Raalte, M. Brands, M.H.A. Muskiet, I.P. Kema, M.J. Serlie, M. Diamant, S.J.L. Bakker, F.A.J. Muskiet Source Type: research