Lack of evidence of association between ifng and il28b polymorphisms and quantiferon-cmv test results in seropositive transplant patients.

LACK OF EVIDENCE OF ASSOCIATION BETWEEN IFNG AND IL28B POLYMORPHISMS AND QUANTIFERON-CMV TEST RESULTS IN SEROPOSITIVE TRANSPLANT PATIENTS. Hum Immunol. 2018 Mar 29;: Authors: Aguado R, Páez-Vega A, Agüera ML, Montejo M, Guirado L, Fortún J, Suárez-Benjumea A, Len O, Fariñas MC, de Gracia C, Hernández D, Cobos-Ceballos MJ, Torre-Cisneros J, Cantisán S, Spanish Network for Research in Infectious Diseases, Spanish Renal Disease Network. Spanish Transplantation Infection Study Group (GESITRA) of the Spanish Society of Infectious Diseases, Clinical Microbiology (SEIMC) Abstract The aim of this study was to analyze the relationship between the IFNG+874 T/A and IL28B (rs12979860) C/T polymorphisms and the secretion of IFNG by CD8+ T cells after stimulation with cytomegalovirus (CMV) peptides, measured using QuantiFERON-CMV (QF-CMV) assay. A total of 184 CMV-seropositive solid organ transplant patients (108 kidney, 68 liver and 8 lung) were recruited. Of them, 151 patients were QF-CMV Reactive (IFNG ≥0.2 UI/mL) and 33 were Non-reactive. Genotype frequencies in the study population were TT (26.6%), AT (50.0%) and AA (23.4%) for IFNG+874 and CC (52.7%), CT (39.1%) and TT (8.2%) for IL28B (rs12979860). These frequencies did not significantly differ between QF-CMV Reactive and Non-reactive patients. Nor were any significant differences observed in the quantitative IFNG level among the genotypes in either the IFNG or the IL28 genes. When...
Source: Human Immunology - Category: Allergy & Immunology Authors: Tags: Hum Immunol Source Type: research