Uncovering a mechanism causing chronic graft-vs-host disease after bone marrow transplant

(Medical University of South Carolina) MicroRNA-17-92 is required for the T-cell and B-cell pathogenicity that drives chronic graft-versus-host disease (cGVHD) after allogeneic bone marrow transplant (BMT), report investigators at The Medical University of South Carolina in an article prepublished online March 12, 2018 by Blood. Data from cGVHD mouse models showed that, by determining T-cell and B-cell differentiation and function, miR-17-92 is responsible for cGVHD development. Inhibiting miR-17 is a potential therapeutic strategy for preventing cGVHD in BMT patients.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news