SMAD4 gene mutation renders pancreatic cancer resistance to radiotherapy through promotion of autophagy.

CONCLUSIONS: Our results demonstrate that defective SMAD4 is responsible for radioresistance in pancreatic cancer through induction of ROS and increased level of radiation-induced autophagy.
PMID: 29602802 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - March 30, 2018 Category: Cancer & Oncology Authors: Wang F, Xia X, Yang C, Shen J, Mai J, Kim HC, Kirui D, Kang Y, Fleming JB, Koay EJ, Mitra S, Ferrari M, Shen H Tags: Clin Cancer Res Source Type: research