Statin Use Associated With a Decreased Risk of Community-Acquired Staphylococcus aureus Bacteremia

We read with great interest the recent article by Smit et  al1 on statin use associated with a decreased risk of community-acquired Staphylococcus aureus bacteremia (CA-SAB), particularly in patients with chronic kidney disease and patients with diabetes. They explained that these results were unlikely due to direct antimicrobial effects of statins on S a ureus but more likely due to the pleiotropic effects of statins reducing important isoprenoid intermediates, resulting in decreased bacterial invasion and inducing neutrophil extracellular traps.

Source: Mayo Clinic Proceedings - April 1, 2018 Category: Internal Medicine Authors: Humphrey H.T. Ko, Ricky R. Lareu, Brett R. Dix, Jeffery D. Hughes Tags: Letter to the Editor Source Type: research