Daratumumab for POEMS Syndrome

The syndrome of polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes (POEMS) is a rare disorder. It is considered paraneoplastic to a usually IgA λ-secreting monoclonal plasma cell dyscrasia.1 High-dose melphalan followed by autologous stem cell transplant (ASCT) is the standard of care in disseminated POEMS syndrome but can be associated with significant treatment-related morbidity and mortality.2 No paradigm exists for managing patients wh o experience relapse and those ineligible for ASCT.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Letter to the Editor Source Type: research