Clinical trials for inner ear drugs: Design and execution challenges.

Clinical trials for inner ear drugs: Design and execution challenges. Hear Res. 2018 Mar 22;: Authors: Jung DH, Rauch SD Abstract The development of therapies for the inner ear presents unique opportunities and challenges. On the one hand, the ear presents an opportunity for localized drug delivery to avoid systemic side effects. However, we do not understand the pathobiology of many common ear disorders clearly enough to develop rational therapeutic solutions. Further, identification of biomarkers beyond conventional audiometry and balance testing to track disease progress and recovery remain elusive. Because of the comparatively low incidence and prevalence of many inner ear disorders, as well as issues with respect to timing of drug delivery for certain diseases, multi-center, multi-investigator collaborative networks are required to promote effective clinical trial design. PMID: 29602591 [PubMed - as supplied by publisher]
Source: Hearing Research - Category: Audiology Authors: Tags: Hear Res Source Type: research