Evaluation of complete blood count parameters to predict endometrial cancer

Journal of Clinical Laboratory Analysis, EarlyView.
Source: Journal of Clinical Laboratory Analysis - Category: Laboratory Medicine Source Type: research

Related Links:

Conclusions: LC was successfully prepared and played biological roles against EC probably through negative regulation of the NF- κB pathwayin vitro andin vivo, which demonstrates its potential therapeutic effects in EC.Cell Physiol Biochem 2018;48:569 –582
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Publication date: 17 July 2018Source: Cell Reports, Volume 24, Issue 3Author(s): Alice H. Hsu, Michelle A. Lum, Kang-Sup Shim, Peter J. Frederick, Carl D. Morrison, Baojiang Chen, Subodh M. Lele, Yuri M. Sheinin, Takiko Daikoku, Sudhansu K. Dey, Gustavo Leone, Adrian R. Black, Jennifer D. BlackSummaryProtein kinase C (PKC) isozymes are commonly recognized as oncoproteins based on their activation by tumor-promoting phorbol esters. However, accumulating evidence indicates that PKCs can be inhibitory in some cancers, with recent findings propelling a shift in focus to understanding tumor suppressive functions of these enzyme...
Source: Cell Reports - Category: Cytology Source Type: research
In this study we modified the capture –recapture method from ecology to estimate the number of families in central Ohio with Lynch syndrome (LS). We screened 1566 colorectal cancer cases and 545 endometrial cancer cases in central Ohio from 1999 to 2005 and identified 58 with LS. We screened an additional 3346 colorectal and 342 endom etrial cancer cases from 2013 to 2016 and identified 149 with LS. We found 12 LS mutations shared between families observed in the first and second studies. We identified three individuals between studies who were closely related and eight who were more distantly related. We used identi...
Source: Familial Cancer - Category: Cancer & Oncology Source Type: research
Source: World Neurosurgery - Category: Neurosurgery Authors: Tags: Case Report Source Type: research
AbstractMicrocystic, elongated, fragmented (MELF)-pattern is an unusual morphology of myometrial invasive front in endometrioid endometrial carcinoma (EA). The aim of the study was to investigate potential correlation between MELF-pattern and peritumoral inflammatory immune response. A total of 96 out of 368 patients were included in this study. CD3, CD20, CD57. CD68 and S100 markers were used for the detection of tumor-associated T-lymphocytes (TAT), tumor-associated B-lymphocytes (TAB), tumor-associated NK-lymphocytes (NK), tumor-associated macrophages and dendritic cells respectively. Mann-Whitney tests, receiver operat...
Source: Cancer Microenvironment - Category: Cancer & Oncology Source Type: research
Conditions:   Deleterious BRCA1 Gene Mutation;   Deleterious BRCA2 Gene Mutation;   Endometrial Adenocarcinoma;   High Grade Ovarian Serous Adenocarcinoma;   Primary Peritoneal High Grade Serous Adenocarcinoma;   Recurrent Endometrial Carcinoma;   Recurrent Fallopian Tube Carcinoma;   R ecurrent Ovarian Carcinoma;   Recurrent Primary Peritoneal Carcinoma Interventions:   Drug: Copanlisib;   Drug: Niraparib Sponsors:   M.D. Anderson Cancer&nb...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Siti Syazani Suhaimi, Nurul-Syakima Ab Mutalib, Sheau S. Khor, Reena Rahayu Md Zain, Saiful Effendi Syafruddin, Nadiah Abu, Ahmad Zailani Hatta Mohd Dali, Rahman Jamal
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSION: Bariatric surgery is associated with decreased risk of hormone-related cancers, whereas gastric bypass might increase the risk of colorectal cancer. PMID: 30003539 [PubMed - as supplied by publisher]
Source: The British Journal of Surgery - Category: Surgery Authors: Tags: Br J Surg Source Type: research
Publication date: Available online 12 July 2018Source: Cancer CellAuthor(s): Francesca Menghi, Floris P. Barthel, Vinod Yadav, Ming Tang, Bo Ji, Zhonghui Tang, Gregory W. Carter, Yijun Ruan, Ralph Scully, Roel G.W. Verhaak, Jos Jonkers, Edison T. LiuSummaryThe tandem duplicator phenotype (TDP) is a genome-wide instability configuration primarily observed in breast, ovarian, and endometrial carcinomas. Here, we stratify TDP tumors by classifying their tandem duplications (TDs) into three span intervals, with modal values of 11 kb, 231 kb, and 1.7 Mb, respectively. TDPs with ∼11 kb TDs feature loss of TP53 and BRCA1. TDP...
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
ConclusionThe combination of hysteroscopic resection with LNG-IUD as fertility-sparing treatment of EEC and AEH showed similar response and live birth rates compared to those reported in literature for progestins alone, but a considerably lower relapse rate. We advocate the use of this combined approach as an alternative fertility-sparing option in patients with ECC and AEH.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
More News: Cancer | Cancer & Oncology | Endometrial Cancer | Laboratory Medicine