Evaluation of complete blood count parameters to predict endometrial cancer
Journal of Clinical Laboratory Analysis, EarlyView.
The optimum adjuvant treatment for Stage II endometrial cancer patients is unknown. External beam radiation therapy (EBRT) is often considered the standard of care; however, retrospective series suggest that brachytherapy (BT) alone may be sufficient for selected patients. As randomized data are lacking, we used a large database to explore this question.
Condition: Endometrial Cancer Interventions: Drug: Carboplatin; Drug: Paclitaxel; Drug: Avelumab Sponsor: National Cancer Institute, Naples Not yet recruiting
Authors: Shi Z, Li C, Tarwater L, Li J, Li Y, Kaliney W, Chandrashekar DS, Stack MS Abstract We performed RNA-seq on an Illumina platform for 7 patients with endometrioid endometrial carcinoma for which both tumor tissue and adjacent noncancer tissue were available. A total of 66 genes were differentially expressed with significance level at adjusted p value
Cutaneous squamous cell carcinoma (SCC) rates are 3-fold greater in men compared to women, with higher mortality rates as well. Whether this gender-linked susceptibility to skin cancer results from differences in estrogen signaling is unclear. A recently identified estrogen receptor (ER) variant known as ER- α36 increases gastric, endometrial, and ER-negative breast cancer growth by expanding the cancer stem cell (CSC) population. We hypothesized that ER-α36 expands the CSC population in cutaneous SCC cells to increase skin tumor growth, such that targeting ER-α36 with the anti-cancer drug icaritin b locks SCC growth.
Conclusions: Feasibility of recruitment into a study of vaginal dilator use was high. Adherence was low, and there was no difference between groups. Adherence to vaginal dilator use requires novel interventions to test. Implications for Practice: Nursing education that includes how dilators may maintain vaginal health may improve use because it was a motivator for adherence in this study.
AbstractLymphadenectomy is considered an integral part of comprehensive surgical staging of endometrial cancer but debate on the value of lymphadenectomy continues in early-stage endometrial cancer. The aim of our study was to determine the number of node positive patients in clinically early-stage low-grade (G1 –G2) endometrioid endometrial cancer. We retro-prospectively analyzed the medical records of 155 women with endometrial pathology coming to the BLK cancer center between January 2015 and December 2017 and studied 60 patients of FIGO grade 1–2 endometrioid endometrial cancer confined to the uteru s to de...
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in adult women (1). It can't be cured, but thanks to many years of fruitful research and intensive investigation, multiple modalities to help manage the condition throughout a woman's lifetime have emerged. Those of us who have been in practice for more than a decade or two have likely had the experience of managing mothers and daughters with the condition. Many of us have supported our PCOS patients through an adolescence complicated by acne and hair growth, an early adulthood complicated by infertility and irregular menses, and late reproductive age compl...
Previous studies have suggested that metformin may be useful for preventing and treating endometrial cancer (EC), while the results have been inconsistent. This systematic review and meta-analysis aimed to inv...
Condition: Endometrial Neoplasms Intervention: Diagnostic Test: Measure of biomarkers in serum and endometrial tissue Sponsor: Fundación Investigación Sanitaria en León Recruiting
Condition: Endometrial Neoplasm Malignant Intervention: Diagnostic Test: Measure of biomarkers in serum and endometrial tissue Sponsor: Fundación Investigación Sanitaria en León Recruiting