Fight Aging! Newsletter, April 2nd 2018

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is published under the Creative Commons Attribution 4.0 International License. You are encouraged to republish and rewrite it in any way you see fit, the only requirements being that you provide attribution and a link to Fight Aging! To subscribe or unsubscribe please visit: https://www.fightaging.org/newsletter/ Contents What Causes the Chronic Inflammation of Aging? Mitochondrial Peptides and the Still Unrealized Vision of Therapeutic Autophagy How Much of the Effect of Calorie Restriction is Due to Suppression of Senescent Cells? Results from a Preliminary Human Trial of Nicotinamide Riboside Supplementation An Interview on the Unknowns of the Epigenetic Clock A Short Report from the Undoing Aging Conference Vascular Degeneration in the Brain Correlates with Behavioral Change in Old Mice Ischemic Conditioning and Exercise ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Publication date: Available online 22 October 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Shradhanjali Singh, Shanti Bhushan Mishra, Alok MukerjeeAbstractThe plant Clerodendrum serratum (L.) Moon has been traditionally claimed for the treatment of various inflammatory conditions including rheumatoid arthritis, hence in the present study the effect of the crude ethanolic extract (CSEE) from leaves of the plant and its chloroform fraction (CSCF) were evaluated in acute and chronic arthritic model. Preliminary phytochemical screening was performed for CSEE and chloroform fraction (CSCF). Formaldehyde (2%...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
In this study, effects of CDP-choline on the well known negative effects of Rapid Eye Movements (REM) sleep deprivation on learning and memory were investigated. Sleep deprivation was induced by placing adult male Wistar albino rats on 6.5 cm diameter platforms individually for 96 hours according to flower pot method. Learning and memory performances were evaluated using Morris Water Maze (MWM) test during the same period of time. Saline or CDP-choline (100 µmol/kg, 300 µmol/kg or 600 µmol/kg) was administered intraperitoneally 30 minutes prior to the onset of MWM experiments. On completion of behavioral ...
Source: Physiology and Behavior - Category: Physiology Source Type: research
Publication date: Available online 23 October 2019Source: Molecular and Cellular ProbesAuthor(s): Yi ChenAbstractCyclooxygenase-2 (COX-2) is an inducible enzyme that plays a key role in the inflammatory cascade through the generation of prostaglandins. Recent studies have found that COX-2 is closely related to the occurrence and development of tumors, angiogenesis and metastasis of tumors. Overexpressed COX-2 has become a predictive biomarker for progression of pre-malignant towards cancer in some tissues, which makes the detection of COX-2 of great value and clinical significance. This review highlights COX-2-specific flu...
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research
Publication date: Available online 22 October 2019Source: Journal of Molecular BiologyAuthor(s): Owen Conway, Hafize Aysin Akpinar, Vladimir Rogov, Vladimir KirkinAbstractNeurons are electrically excitable, post-mitotic cells that perform sensory, relaying, and motor functions. Because of their unique morphological and functional specialization, cells of this type are sensitive to the stress caused by accumulation of misfolded proteins or damaged organelles. Autophagy is the fundamental mechanism that ensures sequestration of cytosolic material and its subsequent degradation in lysosomes of eukaryotic cells, thereby provid...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 23 October 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): V. Arroyo-Jousse, A. Jaramillo, E. Castaño-Moreno, M. Lépez, K. Carrasco-Negüe, P. CasanelloAbstractMaternal pregestational obesity is a well-known risk factor for offspring obesity, metabolic syndrome, cardiovascular disease and type 2 diabetes. The mechanisms by which maternal obesity can induce alterations in fetal and later neonatal metabolism are not fully elucidated due to its complexity and multifactorial causes. Two adipokines, leptin and adiponectin, are involved i...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
We report the synthesis of 4-thioferulic acid (TFA), a new ferulic acid (FA) derivative, and highlight the differences between the two compounds concerning rate and mechanism of radical scavenging activity,... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01858A, CommunicationJulie E. Laudenschlager, Logan A. Combee, Michael K. Hilinski Sc(OTf)3-promoted [5 + 1] cycloaddition of vinylcyclopropanes with PhINTs is reported, enabling the regioselective preparation of a range of 1,2,3,6-tetrahydropyridine scaffolds under mild conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Publication date: Available online 22 October 2019Source: Saudi Journal of Biological SciencesAuthor(s): Al-Bandari Fahad Al-Arjani, Abeer Hashem, Elsayed Fathi Abd_AllahAbstractArbuscular mycorrhizal fungi (AMF) are one of the most important drivers of soil ecosystem dynamics. AMF have the potential to improve plant growth and development by modulating key hormonal pathways, which result in decreasing the adverse impact of abiotic stress, such as drought. Pot experiments were conducted in this study to investigate the ability of AMF to ameliorate the adverse impact of drought in Ephedra foliate. Non-inoculated AMF E. foli...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Publication date: Available online 22 October 2019Source: Saudi Journal of Biological SciencesAuthor(s): Mohammad I. Al-Obaida, Alaa K.M. Al-Nakhli, Ibrahim A. Arif, Asmaa Faden, Sahar Al-Otaibi, Bushra Al-Eid, Aishah Ekhzaimy, Haseeb A. KhanAbstractPeriodontal disease is a chronic infectious disease, which is characterized by the damaged dental hard tissue by lactic acid generated by microorganisms after the fermentation of carbohydrates rich diet. The risk of periodontal disease is known to be higher in diabetic patients. We compared the diversity of five commonly occurring dental bacteria including Porphyromonas gingiva...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Publication date: Available online 22 October 2019Source: Redox BiologyAuthor(s): Ziwei Wang, M. Corina Litterio, Michael Müller, David Vauzour, Patricia I. OteizaAbstractSecondary bile acids promote gastrointestinal (GI) tract permeabilization both in vivo and in vitro. Consumption of high fat diet s increases bile acid levels in the GI tract which can contribute to intestinal permeabilization and consequent local and systemic inflammation. This work investigated the mechanisms involved in bile acid (deoxycholic acid (DCA))-induced intestinal epithelial cell monolayer permeabilization and the preventive capacity of (...
Source: Redox Biology - Category: Biology Source Type: research
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