Potential pharmacokinetic herb-drug interactions: have we overlooked the importance of human carboxylesterases 1 and 2?

Potential pharmacokinetic herb-drug interactions: have we overlooked the importance of human carboxylesterases 1 and 2? Curr Drug Metab. 2018 Mar 30;: Authors: Xu J, Qiu JC, Ji X, Guo HL, Wang X, Zhang B, Wang T, Chen F Abstract Herbal products have grown steadily across the globe over the past 10 years and have increasingly been incorporated into western medicine for healthcare aims, thereby causing potential pharmacokinetic herb-drug interactions (HDI) through the inhibition or induction of drug-metabolizing enzymes and transporters. Human carboxylesterases 1 (CES1) and 2 (CES2) are versatile enzymes involvement in the metabolism of endogenous and exogenous compounds including many important therapeutic medications. Moreover, the growing number of CES substrate drugs also underscores the importance of CES1 and CES2. Here, we summarized those potential inhibitors and inducers coming from herbal constituents towards CES1 and CES2. We also reviewed those published HDI studies focusing on herbal products and therapeutic agents metabolized by CES1 or CES2. Our results showed that more than 50 natural inhibitors of CES1 or CES2 including phenolic chemicals, triterpenoids, and tanshinones were found from herbs, whereas inducers for both CES1 and CES2 are scarce. Systemic exposure to some commonly used drugs including oseltamivir, irinotecan, and clopidogrel were found to altered in animals when they were co-administered with herb products...
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Metab Source Type: research