O7.4. systematic review, meta-analysis and meta-regression of predictors of placebo response in acute schizophrenia

DiscussionThis meta-regression included approximately two times more studies than previous attempts to resolve this issue and it is therefore the to date by far largest analysis of this kind. Multiple potential moderators of placebo response were identified. Importantly, these moderators of placebo response were not identical with those identified in a previous analysis1 as significant moderators of drug-placebo differences in the same dataset. Thus, different factors appear to play a role in this complex area.References1. Leucht S, Leucht C, Huhn M, Chaimani A, Mavridis D, Helfer B, Samara M,Rabaioli M, B ächer S, Cipriani A, Geddes JR, Salanti G, Davis JM. Sixty Years of Placebo-Controlled Antipsychotic Drug Trials in Acute Schizophrenia: SystematicReview, Bayesian Meta-Analysis, and Meta-Regression of Efficacy Predictors. Am J Psychiatry. 2017;174(10):927–942.
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research