O7.3. dose-response meta-analysis to identify the optimum and equivalent doses of antipsychotic drugs for schizophrenia

DiscussionFrom a conceptual point of view, dose-response meta-analysis is the most appropriate method to identify maximally effective doses and equivalent doses. The results of this meta-analysis will be compared with other published methods to define dose-response, in particular the minimum-effective dose method, the classical mean dose method, the daily-defined-doses (DDD) method and expert consensus methods. The results of this analysis are likely to provide information with impact for treatment decisions.
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research

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ConclusionsThe neural networks associated with the N400 ERP response to semantic violations depends on conceptual relatedness. These findings are consistent with a distributed network underlying neural responses to semantic incongruity including unimodal visual areas as well as integrative, transmodal areas. Unusual thoughts in SZ may reflect impaired processing in transmodal hub regions such as the precuneus, leading to overly broad semantic associations.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 23 July 2019Source: NeuroImage: ClinicalAuthor(s): Kristin K. Lottman, Timothy J. Gawne, Nina V. Kraguljac, Jeffrey F. Killen, Meredith A. Reid, Adrienne C. LahtiAbstractSchizophrenia is often characterized by dysconnections in the brain, which can be estimated via functional connectivity analyses. Commonly measured using resting-state functional magnetic resonance imaging (fMRI) in order to characterize the intrinsic or baseline function of the brain, fMRI functional connectivity has significantly contributed to the understanding of schizophrenia. However, these measures may not capture ...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Conditions:   Schizophrenia;   Bipolar I Disorder Intervention:   Drug: Aripiprazole Sponsors:   Otsuka Pharmaceutical Development&Commercialization, Inc.;   PRA Health Sciences Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In her book Mind Fixers: Psychiatry ’s Troubled Search for the Biology of Mental Illness, historian Anne Harrington challenges psychiatrists to embrace complexity. Her central message is that society has often projected a lot onto psychiatry, with our field far too eager to accept these and to fill an expertise void: at one point, w ith psychoanalytic grandiosity, later with overpromised, underperforming biological boasts and reified diagnostic labels. Echoing Foucault, Harrington invites us to avoid mistaking the name of the thing for the thing itself and to keep struggling for answers, embracing a slow science, mar...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: Book forum Source Type: research
This study tests the existence of effects on domain-level functional network connectivity. Domain functional network connectivity looks for functional connectivity measures of groups of brain networks. This work considers two domain measures: functional connectivity strength and randomness. The first measure is simply an average of connectivities within the domains. The second assesses randomness of the domain specific connectivity matrix. Domains with less random connectivity have higher chance of exhibiting a biologically meaningful connectivity pattern. Consistent with prior observations, individuals with schizophrenia ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Toxoplasma gondii, a common neurotropic parasite, is increasingly being linked to neuropsychiatric disorders, including schizophrenia, Alzheimer’s disease, and Parkinson’s disease. However, the pathogenic mechanisms underlying these associations are not clear. Toxoplasma can reside in the brain for extensive periods in the form of tissue cysts, and this process requires a continuous immune response to prevent the parasite’s reactivation. Because neuroinflammation may promote the onset and progression of neurodegenerative diseases, we investigated neurodegeneration-associated pathological changes in a mous...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Molecular Pathogenesis Source Type: research
Acadia Pharmaceuticals Inc said on Monday its add-on treatment for schizophrenia failed to meet the main goal in a late-stage study.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Researchers from Stanford University in California made the discovery after training rodents to drink water when they saw a vertical black line but not a horizontal one.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Condition:   Randomized Controlled Trial Intervention:   Other: Baduanjin program Sponsors:   National Yang Ming University;   Taipei Veterans General Hospital, Taiwan Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSION: Although single-session tDCS did not improve illness awareness, this pilot study provides mechanistic justification for future investigations to determine if multi-session bi-parietal tDCS can induce sustained changes in brain activity in the PPA in association with improved illness awareness. PMID: 31326732 [PubMed - as supplied by publisher]
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
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