O6.1. hippocampal volume in adolescents with persistent psychotic experiences: a longitudinal population-based mri study

DiscussionThe differences identified in our study suggest that early hippocampal reductions, may play a role in increasing vulnerability to psychosis.References1. van Erp TG, Hibar DP, Rasmussen JM, et al. Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. Mol Psychiatry. 2016;21(4):585.2. Wright IC, Rabe-Hesketh S, Woodruff PW, David AS, Murray RM, Bullmore ET. Meta-analysis of regional brain volumes in schizophrenia. Am J Psychiatry. 2000;157(1):16 –25.3. Nelson MD, Saykin AJ, Flashman LA, Riordan HJ. Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging: a meta-analytic study. Arch Gen Psychiatry. 1998;55(5):433–440.4. Stein JL, Medland SE, Vasquez AA, et al. Identification of common variants associated w ith human hippocampal and intracranial volumes. Nat Genet. 2012;44(5):552–561.5. Drakesmith M, Caeyenberghs K, Dutt A, et al. Schizophrenia-like topological changes in the structural connectome of individuals with subclinical psychotic experiences. Hum Brain Mapp. 2015;36(7):2629–2643.6. Sattert hwaite TD, Wolf DH, Calkins ME, et al. Structural Brain Abnormalities in Youth With Psychosis Spectrum Symptoms. JAMA psychiatry. 2016;73(5):515–524.
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research