O5.3. a comprehensive nationwide study of comorbidity within treated mental disorders – a danish register-based study

We examined associations between all pairs of mental disorders. Hazard ratios (HR) were estimated using Cox Proportional Hazards models with age as time scale, and adjusting for sex, calendar time and other psychiatric comorbidity. Finally, we estimated the absolute risk of being diagnosed with other mental disorders after being diagnosed with a specific disorder.ResultsAll mental disorders were associated between them, with HR ranging from 1.1 to 19.5. There were 21,909 men and 20,106 women who were diagnosed with schizophrenia spectrum disorder (SSD) for the first time between 2000 and 2016. After onset of SSD, the rate of being diagnosed with substance abuse disorders was more than 4 times higher, compared to those without SSD (HR=4.4 [95%CI: 4.3 –4.5]); the difference was larger within the first 6 months after being diagnosed with SSD (HR=31.8 [95%CI: 30.5–33.1]), although the rates remained higher even 15 years after the diagnosis (HR=3.2 [95%CI: 3.0–3.4]). Within the first 10 years after diagnosis of SSD, 23.8% [95%CI: 23.1–24.5] of men and 10.6% [95%CI: 10.2–11.1] of women were diagnosed for the first time with substance abuse disorders. Regarding mood disorders, the incidence rate was almost 3 times higher on individuals previously diagnosed with SSD than undiagnosed (HR=2.7 [95%CI: 2.6–2.7]). Analogous time-trends wer e observed, with larger differences within the first 6 months after diagnosis (HR=18.8 [95%CI: 18.1–19.6]), which diminished but remained...
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research