O4.7. placental gene expression, obstetrical history and polygenic risk for schizophrenia

DiscussionOur data suggest that the most significant schizophrenia GWAS variants contribute to risk at least partly by converging on a developmental trajectory sensitive to ELCs and altered placental gene expression. The sex-associated effects on placental transcription suggest that the male preponderance of schizophrenia may arise from gene-environment interactions that influence placental biology. These results highlight placental health as a new public health frontier for primary prevention, particularly in high-risk males.
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research