F234. typical and atypical antipsychotics ’ d2r affinity and doses influences postsynaptic density by modulating the spatial expression of homer1a a gene highly implicated in synaptic plasticity and psychosis

DiscussionA strong correlation with D2 receptor blockade and the extent of Homer1a expression in striatum, but not in the cortex, was found. However, other molecular mechanisms (e.g. D1 receptor activation in striatum; 5-HT2A receptor blockade in the cortex) may contribute to affect its expression levels.
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research