F234. typical and atypical antipsychotics ’ d2r affinity and doses influences postsynaptic density by modulating the spatial expression of homer1a a gene highly implicated in synaptic plasticity and psychosis

AbstractBackgroundPost-synaptic density (PSD) is an ultra-specialized structure of excitatory synapses composed by a large variety of molecules (scaffolding proteins, glutamate receptors, cytoskeleton proteins). PSD has been implicated in synaptic plasticity, memory formation and in the pathophysiology of psychiatric disorders by extensive GWA studies. The immediate early gene Homer1a is part of this complex molecular machinery for signaling transmission and its expression is modulated by antipsychotics (APDs). Here we show a comparative analysis of Homer1a expression data by first and second-generation APDs, in order to correlate it to their receptor profile.MethodsWe analyzed Homer1a expression induced by APDs at various doses in Sprague-Dawley rat forebrain, collecting data from multiple In Situ Hybridization experiments carried out in our laboratory in standard controlled conditions. Homer1a expression levels were normalized as the ratio of the corresponding mean vehicle value in each region. Normalized expression levels were quantitatively compared by ANOVA and Tukey ’s post-hoc test (p
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research

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Source: European Psychiatry - Category: Psychiatry Source Type: research
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Source: Neurochemistry International - Category: Neuroscience Source Type: research
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Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
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Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
Condition:   Schizophrenia Intervention:   Device: Event-Related Potentials (ERP) and Electroencephalogram (EEG) testing with the COGNISION® System Sponsors:   ERP Biomarker Qualification Consortium;   COGNISION;   Cadent Therapeutics;   Alkermes, Inc.;   Anavex Life Sciences Corp.;   Merck Sharp & Dohme Corp.;   Takeda;   Sage Therapeutics;   H. Lundbeck A/S Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Schizophrenia Interventions:   Behavioral: Social Cognition Training;   Behavioral: Informations Sponsor:   Hôpital le Vinatier Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Schizophrenia Intervention:   Device: Event-Related Potentials (ERP) and Electroencephalogram (EEG) testing with the COGNISION® System Sponsors:   ERP Biomarker Qualification Consortium;   COGNISION;   Cadent Therapeutics;   Alkermes, Inc.;   Anavex Life Sciences Corp.;   Merck Sharp & Dohme Corp.;   Takeda;   Sage Therapeutics;   H. Lundbeck A/S Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Schizophrenia Interventions:   Behavioral: Social Cognition Training;   Behavioral: Informations Sponsor:   Hôpital le Vinatier Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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