F229. the biological underpinnings of treatment response in delusional disorder: a systematic review of qualitative evidence-to-date

DiscussionThe strongests biological contributors for treatment response in delusional disorder seem to be those implicating monoaminergic systems, particularly dopamine and serotonergic neurotransmitters. Although the low level of evidence, the serotonergic dysfunction may be associated with response rates, especially in delusional disorder somatic type. The link between genetic variants of dopamine receptors and neuroimaging findings in delusional disorder may open new avenues for the search of the biological underpinnings of treatment response. The evidence for an integrated model involving dopamine and serotonin systems bears further investigations.
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research

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Condition:   Randomized Controlled Trial Intervention:   Other: Baduanjin program Sponsors:   National Yang Ming University;   Taipei Veterans General Hospital, Taiwan Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSION: Although single-session tDCS did not improve illness awareness, this pilot study provides mechanistic justification for future investigations to determine if multi-session bi-parietal tDCS can induce sustained changes in brain activity in the PPA in association with improved illness awareness. PMID: 31326732 [PubMed - as supplied by publisher]
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
Authors: Naguy A, Alamiri B PMID: 31326772 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Without such data, the ‘smart pill’ is a gimmick that payers will not buy into – literally.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
AbstractHistorical and newly emerging models of schizophrenia suggest it is a disorder characterized by the fragmentation of the experience of the self and the world, leading to the interruption of how a unique life is unfolding in the world. It has been proposed that psychotherapy might therefore promote recovery by facilitating the development of a greater ability to integrate information about the self and others. In this paper we explore how the supervision of a metacognitively-oriented psychotherapy can assist therapists to experience and conceptualize fragmentation within sessions, join patients in the gradual proces...
Source: The American Journal of Psychoanalysis - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 20 July 2019Source: Artificial Intelligence in MedicineAuthor(s): V. Jahmunah, Shu Lih Oh, Rajinikanth V, Edward J. Ciaccio, Kang Hao Cheong, Arunkumar, U. Rajendra AcharyaAbstractExamination of the brain’s condition with the Electroencephalogram (EEG) can be helpful to predict abnormality and cerebral activities. The purpose of this study was to develop an Automated Diagnostic Tool (ADT) to investigate and classify the EEG signal patterns into normal and schizophrenia classes. The ADT implements a sequence of events, such as EEG series splitting, non-linear features mining, t-test ...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
This study looked at the adrenal gland, which produces stress hormones, to see if they were different in deceased persons who had suffered from a severe mental illness. We found that the part of the adrenal gland that produces stress hormones is larger in deceased patients who suffered from schizophrenia, but not other types of psychiatric illnesses, compared to deceased persons with no history of psychiatric illness. PMID: 31322461 [PubMed - as supplied by publisher]
Source: Stress - Category: Research Tags: Stress Source Type: research
Publication date: Available online 19 July 2019Source: Molecular Aspects of MedicineAuthor(s): Ebrahim Hosseini, Zahra Bagheri-Hosseinabadi, Ilario De Toma, Moslem Jafarisani, Iman SadeghiAbstractIn the last decade, transcriptome analyses have discovered thousands of long non-coding RNAs (lncRNAs) which are assumed as a fundamental part of the gene regulatory networks in the cell. Intriguingly, lncRNAs are abundantly enriched in the brain, displaying elaborate spatiotemporal expression profiles and modulation. They diversely participate in the delicate regulation of the central nervous system (CNS) development including se...
Source: Molecular Aspects of Medicine - Category: Molecular Biology Source Type: research
Publication date: 1 December 2019Source: Personality and Individual Differences, Volume 151Author(s): Steffen Moritz, Burghard Andresen, Mary SenguttaAbstractResearch on schizotypal personality and schizotypy has emerged as an important methodological alternative to the investigation of manifest schizophrenia. Contrary to the assumption that schizotypy/schizotypal personality is specifically associated with schizophrenia, some studies have shown that psychiatric controls at times achieve similar scores in schizotypy assessment tools to patients with schizophrenia. We compared patients with schizophrenia, depression, and ob...
Source: Personality and Individual Differences - Category: Psychiatry & Psychology Source Type: research
This week’s Psychology Around the Net has the latest on a new virtual reality therapy trial for people diagnosed with serious mental illnesses, how people with mental health disorders are helping amend their descriptions in diagnostic guidelines, the issues that stop you from setting boundaries and how you can overcome those issues, and more. People With Mental Health Disorders Amend the Descriptions: What would happen if input from people who actually deal with mental health disorders on a daily basis was taken into consideration when it comes to the diagnostic guidelines describing said disorders? A new study set ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Psychology Around the Net Addiction Cannabis cannabis dependency cannabis treatment Loneliness Nhs Procrastination Productivity Psychosis Setting Boundaries Shame virtual reality Source Type: blogs
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