F53. dose reduction of high-dose first-generation antipsychotics or switch to ziprasidone in long-stay patients with schizophrenia: a 1-year double-blind randomized clinical trial

DiscussionIn long-stay patients with severe schizophrenia, reducing high doses of FGA to a dose equivalent of 5 mg/day haloperidol or switching to ziprasidone did not improve negative symptoms. Reducing antipsychotic doses was feasible in most patients, although the risk of relapse is substantial. Neither FGA dose reduction nor ziprasidone seems an adequate alternative to clozapine for treatment-resistant schizophrenia.
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research

Related Links:

Authors: Johansson V, Erhardt S, Engberg G, Kegel M, Bhat M, Schwieler L, Blennow K, Zetterberg H, Cannon TD, Wetterberg L, Hultman CM, Landén M Abstract Preclinical studies indicate a link between the kynurenine pathway and monocyte chemoattractant protein-1 (MCP-1), but there is a lack of clinical studies examining this further. We here perform a secondary analysis of kynurenine metabolites and MCP-1 in cerebrospinal fluid of 23 twins affected from schizophrenia, bipolar disorder or unaffected. We show an association between MCP-1 and kynurenic acid (KYNA), driven by unique environmental influences and a l...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
Authors: Rothärmel M, Krir MW, Moulier V, Védrine MG, Compere V, Guillin O PMID: 31302441 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
CONCLUSIONS: The prevalence of catatonia varies from 5.3% to 19% based on the criteria used. Identification warrants use of structured instruments. Catatonia is more severe in the initial years of illness, those with prior episodes of catatonia and in the younger age group. PMID: 31302436 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Condition:   Schizophrenia Interventions:   Drug: Celecoxib 200mg;   Drug: Placebo oral capsule;   Drug: Minocycline 100mg Sponsor:   Hospital Psiquiatrico Infantil Dr. Juan N. Navarro, Mexico Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Schizophrenia is an'umbrella diagnosis,'with many genetic causes. Targeting specific gene mutations may improve psychosis symptoms, potentially paving the way for future personalized medicine.Medscape Medical News
Source: Medscape FamilyMedicine Headlines - Category: Primary Care Tags: Psychiatry News Source Type: news
(University at Buffalo) A new University at Buffalo-led study describes how researchers wirelessly controlled FGFR1 -- a gene that plays a key role in how humans grow from embryos to adults -- in lab-grown brain tissue.The ability to manipulate the gene, the study's authors say, could lead to new cancer treatments, and ways to prevent and treat mental disorders such as schizophrenia.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
AbstractBackgroundThe 1.6 Mb 3q29 deletion is associated with neurodevelopmental and psychiatric phenotypes, including increased risk for autism spectrum disorder (ASD) and a 20 to 40-fold increased risk for schizophrenia. However, the phenotypic spectrum of the deletion, particularly with respect to ASD, remains poorly described.MethodsWe ascertained individuals with 3q29 deletion syndrome (3q29Del, “cases,”n = 93, 58.1% male) and typically developing controls (n = 64, 51.6% male) through the 3q29 registry (https://3q29deletion.patientcrossroads.org). Self-report of neuropsychiatric...
Source: Molecular Autism - Category: Molecular Biology Source Type: research
Here is a standard emergency department situation, played out all across America today. Patient X has schizophrenia.  He takes medication, but only until he feels better.  He is calm when he takes it, but sometimes aggressive and assaultive when out of treatment and off medications. Patient X decides to leave town and drive somewhere else […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Emergency Medicine Psychiatry Source Type: blogs
Suicide is an important public health problem. The most frequent psychiatric illnesses associated with suicide or severe suicide attempt are mood and psychotic disorders. The purpose of this paper is to provide an educational overview of suicidal behavior ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
BACKGROUND: It is still unknown whether many well-identified risk factors of suicide could be applied to the elderly Chinese patients with schizophrenia. METHODS: 1-month suicidal ideation and lifetime suicide attempts together with their sociodemo...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
More News: Brain | Clinical Trials | Geodon | Neurology | Schizophrenia | Ziprasidone