T21. alterations of cry2 and per3 gene expression are associated with gray matter abnormalities of thalamic-limbic network in unipolar depression and bipolar depression

DiscussionOur study identified the relationship between abnormalities of thalamic-limbic network and alterations of circadian gene pathway in BDP and UDP. The shared GMV abnormality was the right thalamus. PER3 might be critical to hippocampus dysfunction in UDP, and CRY2 might be critical to thalamus dysfunction at a right-hemisphere function in BDP.
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research

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Applied Physiology, Nutrition, and Metabolism, e-First Articles. Nutrition is a modifiable factor for intervention in mental disorders. This scoping review characterized nutrition intervention research in mental disorders. A 3-category framework characterized nutrition interventions: Guide (e.g., counselling), Provide (e.g., food provisions), and Add (e.g., supplementation). Nutrition interventions were classified as single-component (e.g., Guide) or complex (e.g., Guide-Provide). Sixty-nine trials met inclusion criteria, 96% were randomized controlled trials. Most commonly diagnosed mental disorders were depressive disord...
Source: Applied Physiology, Nutrition, and Metabolism - Category: Physiology Authors: Source Type: research
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Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology anxiety biological bipolar-disorder depression Genetics JAMA Psychiatry mental illness mental-disorders National-Institute-of-Mental-Health neuroanatomy psychopathology Resear Source Type: blogs
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Source: Revue d Epidemiologie et de Sante Publique - Category: Epidemiology Tags: Rev Epidemiol Sante Publique Source Type: research
Abstract Lumateperone (ITI-007) is a tosylate salt with binding affinities to receptors implicated in the therapeutic actions of antipsychotic medications, including the serotonin 5HT2A receptors, dopamine D2 and D1 receptors and the serotonin transporter. It has a unique mechanism of action because it simultaneously modulates serotonin, dopamine, and glutamate neurotransmission, implicated in serious mental illness. It can be considered a multi-target-directed ligand and a multifunctional modulator of serotoninergic system with possible precognitive, antipsychotic, antidepressant and anxiolytic properties. Lumate...
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Tags: CNS Neurol Disord Drug Targets Source Type: research
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Source: Metabolic Brain Disease - Category: Neurology Source Type: research
Psychiatric disorders, such as schizophrenia, depression, anxiety, and bipolar disorder, are common conditions that arise as a result of complex and heterogeneous combinations of genetic and environmental factors. In contrast to childhood neurodevelopmental conditions such as autism and intellectual disability, there are no clinical practice guidelines for applying genetic testing in the context of these conditions. But genetic counseling and genetic testing are not synonymous, and people who live with psychiatric disorders and their family members are often interested in what psychiatric genetic counseling can offer. Furt...
Source: Cold Spring Harbor perspectives in medicine - Category: Research Authors: Tags: Genetic Counseling: Clinical Practice and Ethical Considerations PERSPECTIVES Source Type: research
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Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
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Source: The International Journal of Social Psychiatry - Category: Psychiatry Authors: Tags: Int J Soc Psychiatry Source Type: research
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Source: Expert Opinion on Emerging Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Emerg Drugs Source Type: research
  Should people with mental illness have children? In today’s Not Crazy Podcast, Gabe and Lisa discuss their own reasons for not having kids, while also giving a platform to Amy Barnabi, a mother of two with bipolar disorder. Amy discusses her decision to have children and shares her experiences, joys and challenges thus far. What if you can’t be a good parent when your illness flares up? What if the child inherits your diagnosis? If you are a parent with mental illness, you’ve likely heard these questions. Tune in to hear these topics discussed (and much more!) on today’s podcast. (Transcript...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar Children and Teens Disorders Family General Interview Mental Health and Wellness Not Crazy Podcast Source Type: blogs
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