Ca2+ Signalling and Membrane Dynamics During Cytokinesis in Animal Cells.

Ca2+ Signalling and Membrane Dynamics During Cytokinesis in Animal Cells.
Adv Exp Med Biol. 2017;981:389-412
Authors: Webb SE, Miller AL
Abstract
Interest in the role of Ca2+ signalling as a possible regulator of the combinatorial processes that result in the separation of the daughter cells during cytokinesis, extend back almost a 100 years. One of the key processes required for the successful completion of cytokinesis in animal cells (especially in the large holoblastically and meroblastically dividing embryonic cells of a number of amphibian and fish species), is the dynamic remodelling of the plasma membrane. Ca2+ signalling was subsequently demonstrated to regulate various different aspects of cytokinesis in animal cells, and so here we focus specifically on the role of Ca2+ signalling in the remodelling of the plasma membrane. We begin by providing a brief history of the animal models used and the research accomplished by the early twentieth century investigators, with regards to this aspect of animal cell cytokinesis. We then review the most recent progress made (i.e., in the last 10 years), which has significantly advanced our current understanding on the role of cytokinetic Ca2+ signalling in membrane remodelling. To this end, we initially summarize what is currently known about the Ca2+ transients generated during animal cell cytokinesis, and then we describe the latest findings regarding the source of Ca2+ generating these...

Source: Advances in Experimental Medicine and Biology - April 1, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research