Pigments from Filamentous Ascomycetes for Combination Therapy.

Pigments from Filamentous Ascomycetes for Combination Therapy. Curr Med Chem. 2018 Mar 29;: Authors: Hromadka R, Kejík Z, Jakubek M, Kaplanek R, Sandrikova V, Urban M, Martasek P, Kral V Abstract Filamentous ascomycetes (Neurospora and Monascus) have been studied for a long time because of their production of secondary metabolites such as microbial pigments. The ascomycetes represent an interesting group of compounds with high potential for medicinal applications. Many recent studies have shown their efficacy in the treatment of serious pathological states such as oncological diseases, neurodegenerative diseases and hyperlipidaemia. Nevertheless, the clinical usability of ascomycetes is still limited. However, this problem can be solved by use of these compounds with combinations of other therapeutic agents. This strategy can supress their side effects and improve their therapeutic efficiency. Moreover, their co-application can significantly enhance conventional therapies that are used. This review summarizes and discusses the general principles of this approach, introduced and supported by numerous examples. In addition, the prediction of the future potential application of this methodology is included. PMID: 29600749 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research