Combination exposure of melamine and cyanuric acid is associated with polyuria and activation of NLRP3 inflammasome in rats.

In conclusion, Mel+CA treatment caused urine concentrating defect and reduced expression of renal AQPs and key sodium transporters, which is likely due to the inflammatory responses and activation of NLRP3 inflammasome induced by crystals formed in the kidney.
PMID: 29592526 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - March 28, 2018 Category: Urology & Nephrology Authors: Wang F, Liu Q, Jin L, Hu S, Luo R, Han M, Zhai Y, Wang W, Li C Tags: Am J Physiol Renal Physiol Source Type: research