Absence of 1p/19q codeletion in oligodendroglioma-like areas of pilocytic astrocytomas.

This study aims to determine if the oligodendroglioma-like areas present in some pilocytic astrocytomas (PA) possess the signature 1p/19q codeletion that is characteristic of classical oligodendroglioma. Array comparative genomic hybridization was carried out on 12 PA samples, from which oligodendroglioma-like areas were microdissected and used as the template DNA source. 1p/19q codeletions were not found in any of the oligodendroglioma areas in PAs. We conclude that PAs with oligodendroglioma-like areas do not share the same molecular genetics as classic oligodendroglioma. . PMID: 29595124 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29595124?dopt=Abstract

Source: Clinical Neuropathology - March 29, 2018 Category: Pathology Authors: Frazer B, Kearney H, Cryan J, Beausang A, Brett F, Farrell MA, Buckley PG Tags: Clin Neuropathol Source Type: research