High Frequencies of Regulatory T Cells Are Associated with Less Chronic Lung Allograft Dysfunction in Cystic Fibrosis Patients After Combined Lung and Liver Transplantation
In this study we investigated regulatory t cells after combined lung and liver transplantation, or after isolated lung transplantation, in cystic fibrosis patients and correlated the findings with long term outcomes
Publication date: Available online 20 February 2019Source: Canadian Journal of DiabetesAuthor(s): Julie Gilmour
George Monckton, from West Midlands, could be saved from lung deterioration by Orkambi. It is unavailable on the NHS due to a deadlock on a price deal with US manufacturers Vertex.
We describe a method for simultaneously depleting DNA from intact human cells and extracellular DNA (human and bacterial) in sputum, using selective lysis of eukaryotic cells and endonuclease digestion. We show that this method increases microbial sequencing depth and, consequently, both the number of taxa detected and coverage of individual genes such as those involved in antibiotic resistance. This finding underscores the substantial impact of DNA from sources other than live bacteria in microbiological analyses of complex, chronic infection specimens.Graphical Abstract
Natalia Molchanova, Hengzhuang Wang, Paul R. Hansen, Niels H øiby, Hanne M. Nielsen, Henrik Franzyk
THE parents of a little girl with cystic fibrosis have revealed their daily battle to keep her healthy as they wait for life-saving drug Orkambi
This study identifies educational needs and preferences of interprofessional CF providers regarding SRH in AYA women with CF.
We have read with great interest the case report by Pujol et al entitled Synchronous multiple non-small cell lung cancers in an allograft lung recipient , about a young cystic fibrosis lung transplant recipient who developed metastatic lung cancer. We would like to comment on this ‘rare’ long-term complication post lung transplantation. Recent registry data from the International Society of Heart and Lung Transplantation showed that the overall incidence of a malignancy post lung transplantation at 1, 5 and 10 years is 5.3%, 19.6% and 31.7% respectively  In observation al studies the incidence of lung can...
Conditions: Cystic Fibrosis; Hypoxemia; Lung Diseases Intervention: Other: Pre-flight evaluation Sponsors: Oslo University Hospital; The Norwegian Resouce Centre for Cystic Fibrosis; Norwegian National Adivisory Unit on Rare Disorders; LHL Hospital Gardermoen Not yet recruiting
Publication date: Available online 16 February 2019Source: Journal de Mycologie MédicaleAuthor(s): M. Hassanzad, V. Mortezaee, F. Bongomin, M. Poorabdollah, S. Sharifynia, M. Maleki, N. Hedayati, A.A. Velayati, M.T. HedayatiAbstractA 12-year-old boy with cystic fibrosis (CF) and a history of glucocorticoid-dependent allergic bronchopulmonary aspergillosis (ABPA) was referred to our hospital. The ABPA was diagnosed when he was 8 years old and he had been treated with several course of oral glucocorticoids for recurrent exacerbations. He was readmitted when aged 12 with a history of worsening shortness of breath and c...
We present our experience with distal splenorenal shunting (DSRS) for the treatment of PHT as an alternative to liver transplantation (LT).