Donor Derived Cell Free DNA is Elevated With Pathogens That are Risk Factors For Chronic Lung Allograft Dysfunction

Infections remain an important risk factor for chronic lung allograft dysfunction (CLAD) and mortality following lung transplantation. In particular, Pseudomonas aeruginosa, Aspergillus fumigatus, respiratory viruses and cytomegalovirus remain published risk factors for CLAD. Recent studies have shown that plasma levels of the donor fraction of cell free DNA (%ddcfDNA) are increased during episodes of acute lung rejection and other allograft injury. We hypothesize that plasma %ddcfDNA may be higher in subjects with pathogen associated allograft injury.

Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: P. Shah, M. Rohly, A. Brown, I. Timofte, M. Nayyar, A. Gandhi, N. Kim, A. Joshi, A. Iacono, S. Nathan, R. Avery, J. Orens, S. Agbor-Enoh, H. Valantine Source Type: research