Bacteriophage Treatment in a Lung Transplant Recipient

We describe the case of a 67-year old male bilateral lung transplant recipient (LTR) who developed recurrent episodes of multi-drug resistant (MDR) Pseudomonas aeruginosa (PA) pneumonia in the setting of right anastomotic stricture requiring airway stent placement and chronic lung allograft dysfunction. We obtained an emergency Investigational New Drug approval from the US Food and Drug Administration to use sequential bacteriophage combinations (BC) as adjunctive treatment to systemic antibiotics.

Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: S. Aslam, G. Yung, J. Dan, S. Reed, M. LeFebvre, C. Logan, R. Taplitz, N. Law, E. Golts, K. Afshar, S. Lehman, S. Morales, C. Furr, F. Rosas, A. Gaidamaka, I. Bilinsky, P. Grint, B. Biswas, C. Duplessis, T. Hamilton, R. Schooley Source Type: research