Recipient Emphysema Differentially Affects Immunologic Responses During Acute Lung Allograft Rejection in a Pre-Clinical Model

Immune-modifying processes such as IPF and COPD result in a recipient environment that can be hostile to allografts by, as of yet, ill-defined mechanisms. In an era driving towards personalized medicine, a better understanding of the potentially differing immune mechanisms in different populations may identify novel therapeutic approaches to improve outcomes. Here we utilize a systems biology approach to determine the impact of recipient pre-transplant emphysema on post transplant graft survival.

Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: K.J. Patel, Q. Cheng, D.P. Allen, A. Aliweah, H. Knochelmann, C. Paulos, M. Goddard, S.N. Nadig, C. Atkinson Source Type: research