Intracellular C3 Protects Human Airway Epithelial Cells from Oxidant-Stress Induced Apoptosis: Implications for Lung Allograft Injury

Complement activation is a fundamental mechanism for host defense and modulation of environmental stress following lung transplantation. We recently found that intracellular C3 has additional functions in mediating CD4+T cell homeostasis and cytokine production. However, the role of intracellular C3 in airway epithelial cells (AEC) has not been defined. Here we examined intracellular C3 in the setting of oxidant-induced stress, which is implicated in ischemia-reperfusion injury (IRI) and bronchiolitis obliterans syndrome (BOS).

Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: H.S. Kulkarni, C. Frakouh, D.E. Byers, S.L. Brody, A.E. Gelman, J.P. Atkinson Source Type: research