Organ-specific Differences in a Thymoglobulin and Belatacept-based Protocol for Tolerance Induction in Non-human Primates

In non-human primate lung transplantation, allograft acceptance has been achieved using a delayed mixed-chimerism approach consisting of 4 months of triple-drug immunosuppression (FK, MMF, steroids) followed by donor bone marrow transplantation (DBMT) along with equine-ATG, anti-IL6R mAb, anti-CD154 mAb and anti-CD8 mAb. With this protocol, 3 out of 4 monkeys accepted their grafts long-term (>299,>813,>464 days). However, anti-CD154mAb and anti-CD8 mAb are not clinically available. In kidney transplantation, persistent allograft acceptance in Cynomolgus macaques was achieved using an alternative immunosuppression protocol relying on the clinically available reagents, rabbit-ATG and belatacept.

Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: W. Sommer, J.M. O, K. Huh, K.A. Robinson, A. Dehnadi, I.M. Hanekamp, I.A. Rosales, K.B. Pruner, J.T. Paster, R.N. Smith, R.B. Colvin, T. Kawai, G. Benichou, J.C. Madsen, J.S. Allan Source Type: research