Genetic Epidemiologyof Ventricular Tachycardia in Patients with Cardiomyopathy in Kazakhstan: ATargeted Sequencing Study

Ventricular tachycardia (VT) is a common symptom in cardiac disorders of different etiology. Abnormalities of cardiac ion channels are attributed to mutations in the genes encoding the channel protein and cause altered function of channels, which can predispose to arrhythmias. Molecular alterations of cardiac ion channels proteins are known to cause VT in several congenital cardiomyopathies. Aim: to investigate genetic basis of VT in patients with cardiomyopathy in Kazakhstan using targeted high throughput next generation sequencing (NGS) (design of new gene panel).

Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: M. Bekbossynova, A. Akilzhanova, C. Guelly, Z. Abilova, A. Akhmetova, U. Kairov, O. Nuralinov, G. Rashbayeva, S. Trajanoski, B. Abdirova, Z. Zhumadilov Source Type: research