Bile Acid Aspiration is Associated with Airway Infections: A Targeted Metabolomic Approach

Gastroesophageal reflux and bile acid aspiration are risk factors for chronic lung allograft dysfunction. Bile acids may compromise the broncho-alveolar innate immunity by deranging the lipid surface barrier and/or by directly modulating macrophage activity. Targeted bile acid metabolomics and bacterial, fungal and viral cultures were investigated in post lung transplant surveillance bronchial washings.

Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: A. Urso, D.F. Briganti, J. Costa, R. Nandakumar, H. Robbins, L. Shah, J.R. Sonett, S. Cremers, S. Arcasoy, F. D'Ovidio Source Type: research